Rapid haemostat using mipor starch with high specific surface area as main raw material and preparation process thereof

A technology of high specific surface area and microporous starch, which can be used in medical preparations containing active ingredients, blood diseases, extracellular fluid diseases, etc., and can solve the problems that there is no existing fast, effective and cheap hemostatic agent, and achieve wound healing Fast healing, less chance of wound infection, accelerated healing effect

Inactive Publication Date: 2009-12-23
SHANXI LIFEGEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a rapid hemostatic agent with high specific surface area microporous starch as the main raw material and its prep

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A kind of high specific surface area wheat microporous starch is the preparation process of the rapid hemostatic agent of main raw material, can carry out according to the following steps:

[0046] ①Activation of high specific surface area wheat microporous starch

[0047] Weigh 1.0 kg of high specific surface area wheat microporous starch, leave it in a vacuum desiccator at room temperature for 24 hours, then wash it twice with 5 times the volume of absolute ethanol and three times with 12 times the volume of acetone, and then wash it with G2 sand Filter the funnel until dry, leave it in a vacuum desiccator at 45°C for 24 hours, and then transfer it to a container filled with high-purity nitrogen;

[0048] ②The addition of recombinant epidermal growth factor

[0049] In the container filled with high-purity nitrogen, add about 100 micrograms of freeze-dried human epidermal growth factor pure dry powder, stir and mix;

[0050] ③Recombinant antimicrobial peptides such as...

Embodiment 2

[0052] Example 2: Hemostasis in Mammals and Humans

[0053] First, this microporous starch hemostatic agent was tested on superficial skin cuts in mice and rabbits to test its safety and effectiveness. Two identical cuts: 10 mm long, 2 mm deep, and 3 cm apart were made on the left forelimb of shaved mice and rabbits. After the blood was sucked, the microporous starch hemostatic agent was sprayed on one wound immediately, and then the two wounds were treated with pressure and the time for each wound to stop bleeding was recorded, and the bleeding time was recorded on 1 day, 3 days, 7 days, respectively. Take pictures of wound healing at 15 days, 30 days, 45 days and 60 days. The test found that the wound coated with this microporous starch hemostatic agent can stop bleeding almost immediately, while the wound without this microporous starch hemostatic agent can stop bleeding after nearly 5 minutes; the wound coated with this microporous starch hemostatic agent It was almost c...

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PUM

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Abstract

The invention relates to a rapid haemostat using mipor starch with a high specific surface area as a main raw material and a preparation process thereof. The rapid haemostat capable of being absorbed by a human body is prepared by using the mipor starch with the high specific surface area as the raw material and adding growth factors stimulating the rapid healing of a wound and an antimicrobial with diminish inflammation and infection-resistant effects. The haemostat not only can more rapidly and effectively arrest bleeding, but also can effectively accelerate the healing, the diminish inflammation and the infection resistance of the wound.

Description

technical field [0001] The invention relates to a rapid hemostatic agent and a preparation process thereof, in particular to a rapid hemostatic agent with high specific surface area microporous starch as a main raw material and a preparation process thereof. Background technique [0002] Blood is an important substance to maintain human life, and the total blood volume of an average adult is about 4000 milliliters. When the human body is traumatized and causes massive bleeding, if 1 / 3 of the total blood volume (about 1300 ml) is lost in a short period of time, the human body will go into shock, manifested as pale face, cold sweat, blood pressure drop, and weak pulse; Losing half of the total blood volume (about 2000 milliliters), human tissues and organs will be in a state of severe ischemia, which can lead to rapid death. [0003] In our daily life, many people are disabled or even life-threatening due to bleeding for various reasons every day. If timely and effective hem...

Claims

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Application Information

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IPC IPC(8): A61K31/718A61K38/17A61K38/18A61P7/04
Inventor 边六交陈超段栋刘成程
Owner SHANXI LIFEGEN
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