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Method for simultaneously carrying out magnetic induction heating, imaging and temperature detecting on tumor cells

A tumor cell, magnetic induction technology, used in heating surgical instruments, applications, sensors, etc.

Inactive Publication Date: 2009-12-16
SOUTHEAST UNIV
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Problems solved by technology

[0007] Technical problem: The purpose of the present invention is to solve the problems of how to heat the cells as a nano-heater after the magnetic nanoparticles enter the cells in the hyperthermia of tumor cells, and how to measure the local temperature experienced by each cell. A method to simultaneously perform magnetic induction heating, imaging and intracellular temperature measurement on tumor cells, so as to further promote the development of tumor magnetic induction hyperthermia technology

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  • Method for simultaneously carrying out magnetic induction heating, imaging and temperature detecting on tumor cells

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Embodiment 1

[0026] (2) A method that can simultaneously perform alternating magnetic field heating and fluorescence measurement. Alternating magnetic field is generated by magnetic induction heating device (frequency 50-200KHz, intensity 0-15KA / m, planar induction coil), fluorescence excitation (such as 488nm) and emission light (such as 567nm emission light of 3nm diameter CdTe nanoparticles) is measured by optical fiber The probe and the non-metallic collection optical path avoid the metal being heated or even melted in the alternating magnetic field, and the optical fiber spectrometer is used for the spectral measurement. In addition, the thermosensitive fluorescence of quantum dots under the action of an alternating magnetic field can also be observed through an inverted fluorescence microscope, and a non-metallic objective lens matching the microscope is required in the experiment. Embodiment 1. Using magnetic alginic acid microspheres as the core, a method for constructing a polymer...

Embodiment 2

[0032] Embodiment 2. Using magnetic polylactic acid microspheres as the core, the method of constructing a polymer shell containing thermosensitive fluorescent quantum dots by chemical coupling method:

[0033] 1) Preparation of Fe by chemical coprecipitation method 3 o 4 Magnetic nanoparticles, once the black nanoparticles are formed, oleic acid is added as a surface modifier, and oil-soluble Fe is obtained after washing with water and alcohol 3 o 4 Magnetic nanoparticles, dispersed in n-hexane.

[0034] 2) Water-soluble cadmium telluride QDs (CdTe QDs) modified with mercaptopropionic acid (MPA) were synthesized by electrochemical method using cathode tellurium as tellurium source. Quantum dots that fluoresce at the emission wavelength.

[0035] 3) Preparation of magnetic polylactic acid microspheres by solvent evaporation method: polylactic acid and oil-soluble Fe 3 o 4 The magnetic nanoparticles are dispersed in a mixed solution of dichloromethane and acetone (the rat...

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Abstract

A method for realizing simultaneous magnetic induction heating, imaging and intracellular temperature detecting on tumor cells by virtue of multi-functional nanospheres is provided aiming at the following problems: how magnetic nanoparticles in hyperthermia heat tumor cells as nano heaters after entering the cells and how the local temperature experienced by each cell is measured, so as to further promote the development of tumor magnetic induction hyperthermia technique. The method comprises the following steps: simultaneously combining the magnetic nanoparticles with the function of magnetic induction heating and fluorescent quantum dots with the functions of imaging and temperature detecting in polymeric or inorganic nanospheres, heating the cells by employing the nanospheres combined on the tumor cells under the alternating magnetic field and simultaneously carrying out imaging and temperature detecting on the cells by employing the fluorescent quantum dots under fluorescence microscopes.

Description

technical field [0001] The invention proposes a multifunctional nanomaterial used for hyperthermia in tumor cells and a method for simultaneously performing magnetic induction heating, imaging and intracellular temperature measurement, belonging to the field of biological and medical nanomaterials and technologies. Background technique [0002] Magnetic induction hyperthermia is a kind of tumor hyperthermia, which is to locate the magnetic medium on the tumor site and generate heat under the action of alternating magnetic field, so that the temperature of the tumor area can reach above 42 ℃, so as to kill tumor cells and achieve the purpose of treatment . [0003] In 1971, Burton earlier studied the interstitial hyperthermia (magnetic interstitial hyperthermia, MIH) of ferromagnetic heat seeds. They put a group of alloy ferromagnets with a diameter of about 1mm and a length of about 1.5cm (called "thermoseed", thermoseed) According to a certain distance, it is evenly implan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/04A61B5/00A61B5/01
Inventor 张宇胡孙铃刘继伟葛玉卿顾洪成陈忠文顾宁马明
Owner SOUTHEAST UNIV
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