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Refined ginkgo biloba extract, powder and preparation method thereof

A technology of extract and ginkgo biloba, which is applied in the field of refined ginkgo biloba extract and its preparation, can solve the problems of highly toxic organic solvents, ignoring the ratio of active ingredients in the extract, hidden safety hazards, etc., and achieve less extraction process steps Effect

Active Publication Date: 2009-12-09
北京中海康医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem in the prior art is that it only focuses on the purification of the extract, ignoring the ratio of active ingredients in the extract. For Chinese medicine extracts, the content and ratio of active ingredients will affect the clinical safety of the drug and validity
Secondly, in the prior art, there are many extraction and purification process steps, or the use of highly toxic organic solvents, which poses a safety hazard for the subsequent clinical application of the extract

Method used

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  • Refined ginkgo biloba extract, powder and preparation method thereof
  • Refined ginkgo biloba extract, powder and preparation method thereof
  • Refined ginkgo biloba extract, powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] After infiltrating the Ginkgo biloba powder with 10 times the amount of 50% ethanol, heat and reflux to extract twice, each time for 2 hours, filter, and combine the filtrate; the filtrate is concentrated under reduced pressure, left standing at room temperature, and filtered; , first eluted with deionized water, then eluted with 55% ethanol, and collected the ethanol eluate enriched with total flavonol glycosides and total lactones of Ginkgo biloba leaves; concentrated under reduced pressure, passed through a polyamide column, and used 50% ethanol Eluted with ethanol, and the eluate was concentrated and dried to obtain the obtained product. According to the content determination method of ginkgo leaf extract in Chinese Pharmacopoeia 2005 edition, the content of total flavonol glycosides is 45.2%, and the content of total lactones is 11.8%.

Embodiment 2

[0068] After infiltrating the Ginkgo biloba powder with 8 times the amount of 65% ethanol, heat and reflux to extract twice, each time for 3 hours, filter, and combine the filtrate; the filtrate is concentrated under reduced pressure, left standing at room temperature, and filtered; , first eluted with deionized water, then eluted with 70% ethanol, and collected the ethanol eluate enriched with total flavonol glycosides and total lactones of Ginkgo biloba leaves; concentrated under reduced pressure, passed through a polyamide column, and used 70% ethanol Eluted with ethanol, and the eluate was concentrated and dried to obtain the obtained product. , that is. According to the determination method of ginkgo leaf extract in Chinese Pharmacopoeia 2005 edition, the content of total flavonol glycosides is 48.7%, and the content of total lactones is 12.2%.

Embodiment 3

[0070] After infiltrating the Ginkgo biloba powder with 12 times the amount of 55% ethanol, heat and reflux to extract twice, each time for 1.5 hours, filter, and combine the filtrate; the filtrate is concentrated under reduced pressure, left standing at room temperature, and filtered; the filtrate is passed through a macroporous resin , first eluted with deionized water, then eluted with 60% ethanol, and collected the ethanol eluate enriched with total flavonol glycosides and total lactones of Ginkgo biloba; concentrated under reduced pressure, added 2 times of water and ethyl acetate to the concentrated solution The ester was extracted twice, the aqueous phase was concentrated, passed through a dextran gel, and eluted with 50%, 70%, and 90% ethanol gradients respectively, the eluent was concentrated to dry the total flavonol glycosides, the ethyl acetate phase was concentrated, and dried to obtain The ginkgolide is obtained by mixing total flavonol glycosides and ginkgolide a...

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Abstract

The invention relates to a refined ginkgo biloba extract and a preparation method thereof, as well as a preparation prepared by the extract and a preparation method thereof. The extract comprises 44-80% of total flavonol glycosides and 11-20% of total lactones. The preparation comprises the refined ginkgo biloba extract with curative effective dose and accessories pharmaceutically acceptable.

Description

technical field [0001] The invention relates to a refined ginkgo leaf extract and a preparation method thereof, a preparation containing the extract and a preparation method thereof. Background technique [0002] Ginkgo biloba is the dry leaf of Ginkgo biloba L. Harvest in autumn when leaves are still green and dry in time. Its properties are more wrinkled or broken, and the whole ones are fan-shaped, 3-5cm long and 5-8cm wide. Green or yellow-green, the upper edge is irregularly curved, and some are concave in the middle, up to 2cm. With dichotomous parallel veins, leaf base cuneate, petiole 2-6cm long. Lightweight. Slight gas, slightly astringent taste. Its functions and indications are "constricting the lung, relieving asthma, and relieving pain. It is used for cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, and hyperlipidemia." [0003] Ginkgo biloba extract is an extract made from the dried leaves of Ginkgo biloba L., a plant of t...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K9/19A61K9/08A61P9/10A61P7/02A61P25/00A61P11/06A61K127/00
Inventor 黄海万祺马红萍
Owner 北京中海康医药科技发展有限公司
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