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Composition containing indapamide and B vitamins as well as application thereof

A technology for B vitamins and indapamide, which is applied to the composition containing indapamide and B vitamins and its application field, can solve the problems of unclear blood pressure mechanism and the like

Inactive Publication Date: 2009-12-02
北京奥萨医药研究中心有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Indapamide is a commonly used antihypertensive drug. It is a sulfonamide derivative with an indole ring. It has a diuretic effect and a certain calcium antagonistic effect. Its exact antihypertensive mechanism is still unclear

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: Preparation of indapamide folic acid tablets (1000 tablets)

[0040] Recipe composition:

[0041] Indapamide 1.25g

[0042] Folic acid 0.4g

[0043] Starch 10g

[0044] Microcrystalline Cellulose 50g

[0045] Sodium carboxymethyl starch (CMS Na) 30g

[0046] 10% povidone K-30 (solvent is absolute ethanol) appropriate amount

[0047] Magnesium Stearate Appropriate amount

[0048] Preparation Process:

[0049] Grind 1.25g of indapamide, 0.4g of folic acid, 50g of lactose, 50g of microcrystalline cellulose, and 10g of starch, pass through a 120-mesh sieve, mix evenly according to the method of equal addition, and use an appropriate amount of 10% polyketone ethanol solution to prepare The soft material is granulated, dried, and sized, and the granules with a water content of about 3% are uniformly mixed with an appropriate amount of magnesium stearate, and prepared into 1000 tablets according to a conventional method.

Embodiment 2

[0050] Embodiment 2: Preparation of indapamide folic acid tablets (1000 tablets)

[0051] Recipe composition:

[0052] Indapamide 2.5g

[0053] Folic acid 0.8g

[0054] Starch 10g

[0055] Microcrystalline Cellulose 50g

[0056] Sodium carboxymethyl starch (CMS Na) 30g

[0057] 10% povidone K-30 (solvent is absolute ethanol) appropriate amount

[0058] Magnesium Stearate Appropriate amount

[0059] The preparation process is the same as in Example 1.

Embodiment 3

[0060] Embodiment 3: Preparation of indapamide VB12 tablets (1000 tablets)

[0061] Recipe composition:

[0062] Indapamide 2.5g

[0063] VB12 6mg

[0064] Starch 10g

[0065] Microcrystalline Cellulose 50g

[0066] Sodium carboxymethyl starch (CMS Na) 30g

[0067] 10% povidone K-30 (solvent is absolute ethanol) appropriate amount

[0068] Magnesium Stearate Appropriate amount

[0069] The preparation process is the same as in Example 1.

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PUM

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Abstract

The invention relates to a drug composition containing indapamide and B vitamins and an application thereof in preparing drugs for treating the HHCY-hyperhomocysteinemia and the elevated homocysteine. The composition of the indapamide and B vitamins can further reduce the Hcy level, and the effect is superior to that of single drug, so that the composition of the indapamide and the B vitamins can not only lower the Hcy level, but also has synergetic effect on reducing Hcy damages. The composition of the invention is a selection for treating Hcy, which provides a more effective treatment protocol for treating high homocysteine. The invention belongs to the pharmaceutical field.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing indapamide and B vitamins and its use in the preparation of medicines for treating hyperhomocysteinemia or homocysteine-increasing diseases. belongs to the field of pharmacy. Background technique [0002] As early as 1969, it was hypothesized that homocysteine ​​(Hcy, a sulfur-containing amino acid) might be a risk factor for cardiovascular disease. Since then, a large number of studies have accumulated objective evidence that plasma homocysteine Cystine levels are closely related to the risk of cardiovascular disease (CVD) and other systemic diseases. [0003] A large number of different types of studies have confirmed that the level of plasma homocysteine ​​is independent of traditional risk factors such as hypertension and hyperlipidemia. A 5 μmol / L increase in Hcy increases the risk of stroke by 59% (OR, 1.59; 95% CI, 1.30- 1.95), the risk of deep vein thrombosis increased by 60% (O...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61K45/06A61P43/00A61P7/00
Inventor 秦献辉王文艳于多徐希平
Owner 北京奥萨医药研究中心有限公司
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