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Composition containing indapamide and statins as well as application thereof

A technology for indapamide and composition, which is applied to the composition containing indapamide and statins and the field of use thereof, and can solve the problems of unclear exact antihypertensive mechanism and the like

Inactive Publication Date: 2009-12-02
北京奥萨医药研究中心有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Indapamide is a commonly used antihypertensive drug. It is a sulfonamide derivative with an indole ring. It has a diuretic effect and a certain calcium antagonistic effect. The exact antihypertensive mechanism is still unclear

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: Preparation of Atorvastatin Indapamide Tablets (1000 tablets)

[0040] Recipe composition:

[0041] Atorvastatin 10g

[0042] Indapamide 1.25g

[0043] Starch 10g

[0044] Microcrystalline Cellulose 50g

[0045] Sodium carboxymethyl starch (CMS Na) 30g

[0046] 10% povidone K-30 (solvent is absolute ethanol) appropriate amount

[0047] Magnesium Stearate Appropriate amount

[0048] Preparation Process:

[0049] Grind 10g of atorvastatin, 1.25g of indapamide 5g, 50g of lactose, 50g of microcrystalline cellulose, and 10g of starch, pass through a 120-mesh sieve, mix evenly according to the method of equal addition, and use an appropriate amount of 10% polyketone ethanol The solution is made into a soft material, granulated, dried, and granulated, and the granules with a water content of about 3% are uniformly mixed with an appropriate amount of magnesium stearate, and then made into 1000 tablets according to a conventional method.

Embodiment 2

[0050] Embodiment 2: Preparation of Atorvastatin Indapamide Tablets (1000 tablets)

[0051] Recipe composition:

[0052] Atorvastatin 10g

[0053] Indapamide 2.5g

[0054] Starch 10g

[0055] Microcrystalline Cellulose 50g

[0056] Sodium carboxymethyl starch (CMS Na) 30g

[0057] 10% povidone K-30 (solvent is absolute ethanol) appropriate amount

[0058] Magnesium Stearate Appropriate amount

[0059] The preparation process is the same as in Example 1.

Embodiment 3

[0060] Embodiment 3: Preparation Rosuvastatin Indapamide Tablets (1000 Tablets)

[0061] Recipe composition:

[0062] Rosuvastatin 10g

[0063] Indapamide 2.5g

[0064] Starch 10g

[0065] Microcrystalline Cellulose 50g

[0066] Sodium carboxymethyl starch (CMS Na) 30g

[0067] 10% povidone K-30 (solvent is absolute ethanol) appropriate amount

[0068] Magnesium Stearate Appropriate amount

[0069] The preparation process is the same as in Example 1.

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PUM

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Abstract

The invention relates to a drug composition containing indapamide and statins and an application thereof in preparing drugs for treating the HHCY-hyperhomocysteinemia or the elevated homocysteine. The composition of the indapamide and the statins can further reduce the Hcy level, and the effect is superior to that of single drug, so that the composition of the indapamide and the statins can not only lower the Hcy level, but also has synergetic effect on reducing the Hcy damages. The composition of the invention is a selection for treating Hcy, which provides a more effective treatment protocol for treating high homocysteine. The invention belongs to the pharmaceutical field.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing indapamide and statins and its use in the preparation of medicines for treating hyperhomocysteinemia or elevated homocysteine. belongs to the field of pharmacy. Background technique [0002] As early as 1969, it was hypothesized that homocysteine ​​(Hcy, a sulfur-containing amino acid) might be a risk factor for cardiovascular disease. Since then, a large number of studies have accumulated objective evidence that plasma homocysteine Cystine levels are closely related to the risk of cardiovascular disease (CVD) and other systemic diseases. [0003] A large number of different types of studies have confirmed that the level of plasma homocysteine ​​is independent of traditional risk factors such as hypertension and hyperlipidemia. A 5 μmol / L increase in Hcy increases the risk of stroke by 59% (OR, 1.59; 95% CI, 1.30- 1.95), the risk of deep vein thrombosis increased by 60% (OR, 1.60; 95% C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K45/06A61K31/47A61K31/40A61K31/505A61P43/00A61P7/00
Inventor 秦献辉王文艳于多徐希平
Owner 北京奥萨医药研究中心有限公司
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