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Inner surface coating technique of medicinal glass bottle

A technology for medicinal glass bottle and inner surface, applied to the field of inner surface coating process, can solve problems such as inability to remove, residue residue, drug stability, etc., to ensure stability and purity, reduce drug residue, and reduce hanging. The effect of the wall phenomenon

Active Publication Date: 2009-11-25
肖特药品包装(浙江)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main disadvantages of the existing uncoated controlled injection bottles are as follows: heating and forming of the glass tube leads to the precipitation of alkaline oxides → residues remain on the inner surface of the glass after annealing → increased alkalinity → cannot be removed during cleaning → alkaline substances pass through Store for a certain period of time or sterilize in a pharmaceutical factory → release alkaline substances into the liquid medicine → lead to drug stability problems

Method used

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  • Inner surface coating technique of medicinal glass bottle
  • Inner surface coating technique of medicinal glass bottle
  • Inner surface coating technique of medicinal glass bottle

Examples

Experimental program
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Effect test

Embodiment 1

[0024] refer to figure 1 , a film coating process for the inner surface of a medicinal glass bottle, comprising the following steps: adding water to an organosiloxane to prepare a 5wt% dispersion solution, filling the dispersion solution in a medicinal glass bottle, and maintaining After 30 minutes, pour out the solution, heat the glass bottle to 400°C, and keep it solidified for 30 minutes to obtain the final product.

[0025] The organosiloxane is polydimethylsiloxane.

[0026] The medicinal glass bottle is pretreated before adding the solution. The pretreatment is to wash with dilute alkali first, and then to wash at high temperature with purified water.

[0027] Glass bottle structure after coating (such as figure 1 shown). Due to the hydrophobic properties of the polysiloxane film material, the liquid level in the bottle is very smooth (such as figure 2 shown), while the uncoated injection bottle has a concave liquid surface due to the hydrophilicity of the glass (s...

Embodiment 2

[0029] refer to figure 1 , a film coating process for the inner surface of a medicinal glass bottle, comprising the steps of: taking an organosiloxane and adding a dispersant and then adding water to prepare an 8wt% dispersion solution, filling the dispersion solution in a medicinal glass bottle, and maintaining After 10 minutes, the solution was poured out, the glass bottle was heated to 360°C, and kept solidified for 50 minutes to obtain the final product.

[0030] The organosiloxane is polydimethylsiloxane.

[0031] The medicinal glass bottle is pretreated before adding the solution. The pretreatment is washing with dilute acid first, and then washing at high temperature with purified water.

Embodiment 3

[0032] Embodiment 3 water resistance test

[0033] According to the national drug packaging container (material) method standard (YBB00242003) of the State Food and Drug Administration, low borosilicate glass bottles, neutral borosilicate glass bottles, high borosilicate glass bottles in the prior art, and embodiment 1 of the present invention The water resistance of the inner surface of the obtained siliconized coated glass bottle was measured, and the results are shown in Figure 4.

[0034] After the film is formed, the water resistance of the inner surface of the siliconized coating control injection bottle of the technical product of the project is significantly improved, and the precipitation of alkaline oxides is significantly reduced. Because the content of diboron trioxide in low borosilicate glass, neutral borosilicate glass and high borosilicate glass is 5-8%, 8-12%, and 12.5% ​​or more respectively, the water resistance is enhanced in turn, and the precipitation of ...

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Abstract

The invention relates to an inner surface coating technique of medicinal glass bottle, comprising the following steps: taking organosiloxane to prepare 2 to 10 wt% of dispersion solution by adding water; coating the solution to the inner surface of the medicinal glass bottle; then obtaining the finished product by heating and curing. The invention can connect a polymer film with a silicon-oxytetrahedron in the glass by dint of a common silicon-oxygen bond when the polymer film material is coated to the inner surface of the glass bottle; since the hydroxyl has certain orienting effect, a layer of compact polyorganosiloxane hydrophobic film in the inner surface of the glass bottle.

Description

(1) Technical field [0001] The invention relates to an inner surface coating process of a medicinal glass bottle. (2) Background technology [0002] With the rapid development of science and technology and the rapid development of China's economy, the high-tech pharmaceutical industry has developed rapidly; foreign-funded and Sino-foreign joint venture pharmaceutical companies have sprung up, high-end biological preparations, blood products, suspension preparations, protein preparations, peptide drugs, freeze-dried preparations All kinds of high-grade and high-efficiency injection drugs are quickly spreading to the world market. Modern pharmaceutical companies require more safe, reliable, efficient and economical pharmaceutical packaging products, which poses new research topics for pharmaceutical packaging container manufacturers. [0003] Especially in recent years, the domestic disclosed and undisclosed emerge in an endless stream of drug injury incidents, to a large ext...

Claims

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Application Information

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IPC IPC(8): C03C17/30
Inventor 陈广新陈新伟
Owner 肖特药品包装(浙江)有限公司
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