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Method for synthesizing citric acid glyceride by immobilized lipase catalysis in multistage fixed bed reactor

A fixed-bed reactor, the technology of glycerol citrate, applied in the synthesis field of glycerol citrate, can solve the problems of difficult separation, complicated steps and the like, and achieve the effects of easy removal, strong specificity, and few by-products

Inactive Publication Date: 2009-10-21
JIANGNAN UNIV
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Problems solved by technology

Using the second technology to produce glyceryl citrate has higher catalytic efficiency, but the steps are cumbersome, and it is easy to form impurity glyceryl acetate, which belongs to the same surfactant as glyceryl citrate, which has similar properties and is not easy to separate

Method used

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  • Method for synthesizing citric acid glyceride by immobilized lipase catalysis in multistage fixed bed reactor

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Embodiment 1

[0022] In a three-stage fixed bed (each fixed bed i.d.×L=2.5cm×20cm) reactor (such as figure 1 As shown), each stage is filled with glass beads, immobilized Candida antarctica lipase Novozym 435, and glass beads from bottom to top. ×L=2.5cm×10cm), the circulating water bath keeps the constant temperature of 54.2°C in the reactor. Containers ①~⑦ are all placed in a 54.2°C water bath to maintain a constant temperature.

[0023] Monoglycerides and citric acid in anhydrous isopropanol, anhydrous isoamyl alcohol or anhydrous tert-amyl alcohol solutions (concentrations are 0.24mol / L, 0.24mol / L and 0.12mol / L respectively) are mixed evenly and then added to 54.2℃ Container ① in the water bath, and then pumped into the first-stage fixed-bed reactor at a flow rate of 2.0mL / min for reaction, and the product flows through the first-stage molecular sieve packed column for dehydration and then enters container ②. The product in container ② is pumped into container ③ at a flow rate of 2.0m...

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Abstract

A method for synthesizing citric acid glyceride by immobilized lipase catalysis in a multistage fixed bed reactor is disclosed, belonging to the technical field of the synthesis of citric acid glyceride. In the invention, monoglyceride and citric acid are used as reaction substrates, organic solvents like anhydrous isopropanol, anhydrous isoamylol or anhydrous tertiary amyl alcohol are used as reaction media, the immobilized lipase is used as a catalyst, and esterification reaction is carried out in the multistage fixed bed reactor to obtain the product of the citric acid glyceride. The invention, which takes the multistage fixed bed as the reactor and is provided with a molecular sieve packed column at the back of the reactors at every stage, facilitates the substrates to contact with the catalyst sufficiently, and meanwhile, removes the water generated from the reaction, in addition, the molecular sieve packed column is regenerated and refreshed periodically which is advantageous for the esterification reaction. Prohibition effect against the esterification reaction can be reduced by the addition of the citric acid and conversion rate is improved. The inventive method has the characteristics of mild condition, strong specificity, few byproducts, high conversion rate and the like.

Description

technical field [0001] The invention discloses a method for synthesizing glyceryl citrate catalyzed by immobilized lipase in a multi-stage fixed-bed reactor, which belongs to the technical field of glycerin citrate synthesis. Background technique [0002] Glyceryl citrate is an esterification product of glycerin, fatty acid and citric acid, which has an amphiphilic molecular structure and belongs to anionic surfactants. Due to its non-toxic, easy biodegradation and good surface activity, glyceryl citrate is widely used in food, medicine, cosmetics, detergents and other fields. [0003] Glyceryl citrate is a new type of surfactant developed in the past ten years in China. Its production method is mainly chemical method: ①Using acetic acid as the reaction medium, adding 0.1% to 1% (w / w) catalyst, such as acid , alkali or metal oxides, etc., directly catalyze the esterification reaction of citric acid and monoglyceride or diglyceride. ②Use acetic anhydride and citric acid to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/64
Inventor 单良金青哲刘元法吴晓娟王兴国潘秋琴黄健花宋志华
Owner JIANGNAN UNIV
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