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Pharmaceutical composition containing azithromycin for vagina

An azithromycin and composition technology, which is applied in the field of pharmaceutical compositions for treating vaginal infections, can solve the problems of short duration of drug effect, cumbersome use, fast melting and the like, and achieves good local therapeutic effect, better effect and prolonged release time Effect

Inactive Publication Date: 2009-10-21
BEIJING WANQUAN SUNSHINE MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, azithromycin has poor solubility and poor absorption
At the same time, the common suppository base is used, which melts quickly and the drug effect lasts for a short time
In the course of treatment, repeated medication is required, which is cumbersome to use

Method used

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  • Pharmaceutical composition containing azithromycin for vagina
  • Pharmaceutical composition containing azithromycin for vagina
  • Pharmaceutical composition containing azithromycin for vagina

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 (the existence form of this embodiment is suppository)

[0016]

[0017] Preparation:

[0018] Heat and melt polyoxyl stearate and glycerin in a water bath at 60°C in the prescribed amount, add sodium carboxymethylcellulose, stir, and mix evenly to serve as a suppository base. Add azithromycin lactobionate, stir evenly, pour it into the mold while it is hot, let it cool, cut off the overflowing part, take it out, and it is ready.

Embodiment 2

[0019] Embodiment 2 (the existence form of this embodiment is a suppository)

[0020]

[0021] Preparation:

[0022] Place the prescribed amount of polyethylene glycol 4000, polyethylene glycol 6000 and glycerin in a water bath at 60°C to heat and melt, add hydroxyethyl cellulose, stir, and mix evenly to serve as a suppository base. Add azithromycin hydrochloride, stir evenly, pour it into the mold while it is hot, let it cool, cut off the overflowing part, take it out, and it is ready.

Embodiment 3

[0023] Embodiment 3 (the existence form of this embodiment is suppository)

[0024]

[0025] Preparation:

[0026] Heat and melt the prescribed amount of polyethylene glycol 4000, polyethylene glycol 6000 and glycerin in a water bath at 60°C, add methyl cellulose, stir, and mix evenly to serve as a suppository base. Add azithromycin fumarate, stir evenly, pour it into the mold while it is hot, let it cool, cut off the overflowing part, take it out, and it is ready.

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PUM

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Abstract

The invention discloses a pharmaceutical composition containing azithromycin and pharmaceutically acceptable salts thereof for vagina, which are used for treating vagina inflammation.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating vaginal infection, in particular to a vaginal pharmaceutical composition containing azithromycin pharmaceutically acceptable salt. Background technique [0002] Azithromycin is a semi-synthetic 15-membered macrolide antibiotic that is effective against Gram-positive aerobic bacteria, infections caused by Gram-positive aerobic bacteria, and anaerobic bacteria. However, azithromycin has poor water solubility and is practically insoluble in water, therefore, the antibiotic is not well absorbed. The azithromycin is made into a pharmaceutically acceptable salt, and the water solubility is greatly improved, which is beneficial to the absorption of the drug. The pharmaceutically acceptable salt of azithromycin has good curative effect on pelvic inflammatory disease and vaginitis caused by Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma hominis. [0003] CN101077352A discloses an ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7052A61K9/06A61K9/02A61P15/02
Inventor 袁筝
Owner BEIJING WANQUAN SUNSHINE MEDICAL TECH CO LTD
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