Medicine granule, preparation method thereof, and preparation containing same
A drug and particle technology, which is applied to the delivery of medical preparations containing active ingredients, pharmaceutical formulations, and pills, etc., can solve the problems of low drug particle content, unpleasant taste, and large drug dosage, and achieve high drug content and taste-masking effect. Good, rounded surface
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Embodiment 1
[0044] 300g (75%) of paracetamol (75%), 88g (22%) of lactose, and 2g (0.5%) of micropowdered silica gel were mixed according to the double amount method by the high shear method, placed in a tangential jet fluidized bed, and the frequency of the fan was 27Hz. The air inlet temperature is 30°C, the atomization pressure is 0.25MPa, the rotary speed is 500rpm, the spray speed is 4g / min, the material is heated to 24°C, and 4g / 100ml hydroxypropylmethylcellulose (viscosity is 5cPs) aqueous solution (containing hypromellose Base cellulose 10g (2.5%)) is sprayed on the dry mixture of heating, makes to form drug particle, heats up and dries, promptly obtains acetaminophen drug particle. The drug content of acetaminophen is 75%, the particle size is 80-180 μm, the angle of repose is 28°, the degree of compression is 8%, and the friability is 1.4%. The agent has high tensile strength.
[0045] Following the above preparation steps, in the tangential jet fluidized bed, adopt fan frequenc...
Embodiment 2
[0050] 380g (95%) of ranitidine, 8g (2%) of starch and 0.24g (0.06%) of talcum powder were mixed by the high shear method according to the method of doubling the amount, placed in a tangential jet fluidized bed, and the frequency of the fan was 15Hz. , the air inlet temperature is 35°C, the atomization pressure is 0.15MPa, the turntable speed is 300rpm, the spray speed is 6g / min, the material is heated to 30°C, and 3g / 100ml hydroxypropylmethylcellulose (viscosity is 50cPs) aqueous solution (containing hydroxypropylmethylcellulose) Methyl cellulose 11.76g (2.94%)) is sprayed on the heated dry mixture to form drug particles, which are heated and dried to obtain ranitidine drug particles. The drug content of ranitidine is 95%, the particle size is 60-240 μm, the angle of repose is 38°, the degree of compression is 15%, and the degree of friability is 10%. High tensile strength.
[0051] Following the above preparation steps, in the tangential jet fluidized bed, adopt fan frequen...
Embodiment 3
[0055] 340g (85%) of aspirin, 53g (13.25%) of microcrystalline cellulose and 1g (0.25%) of magnesium stearate were mixed by the high shear method according to the double amount method, placed in a tangential jet fluidized bed, and the fan frequency was used 30Hz, air inlet temperature 35°C, atomization pressure 0.05MPa, turntable speed 120rpm, liquid spray speed 3g / min, material heated to 30°C, 2g / 100ml hydroxypropylmethylcellulose (viscosity 5cPs) aqueous solution (containing hydroxyl Propylmethylcellulose (1.5%) is sprayed onto the heated dry mixture to form drug particles, which are heated and dried; namely, aspirin drug particles are obtained. The content of aspirin is 85%, the particle size is 100~200 μm, the angle of repose is 35°, the degree of compression is 15%, and the degree of friability is 7%. high.
[0056] Following the aforementioned preparation steps, in a tangential jet fluidized bed, adopt fan frequency 30Hz, air inlet temperature 55°C, atomization pressure...
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