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Sodium alginate microballoon vein suppository containing hemangioma-resisting medicant, preparation method and application thereof

A technology of vascular embolism agent and sodium alginate, which is applied in the field of anti-angioma drug sodium alginate microsphere vascular embolism agent and its preparation, to achieve good biocompatibility, relieve pain and burden, and reduce the number of administrations

Inactive Publication Date: 2009-09-23
BEIJING SHENGYIYAO SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, sodium alginate has not been used as a drug carrier to wrap anti-angioma (sclerosing agent) drugs into microspheres and applied to liver hemangioma, maxillofacial hemangioma, nasopharyngeal fibroangioma, body surface hemangioma, Precedent of interventional embolization therapy for uterine fibroids and hemangiomas in other parts

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of Sodium Alginate Microspheres Containing Pingyangmycin

[0040] 1. Preparations before packing:

[0041] ① Handling of glassware:

[0042] Air-dry the cleaned glassware, put it in a high-temperature oven and bake at 280 degrees Celsius for 3 hours (sterilize and remove heat source);

[0043] ②Preparation of Pingyangmycin drug solution for anti-angioma drug:

[0044] Take by weighing 10 grams of commercially available Pingyangmycin, place it in the above-mentioned glass vessel, add water to dissolve it, and obtain Pingyangmycin drug solution;

[0045] ③ Preparation of sodium alginate solution:

[0046] Weigh 50 grams of commercially available sodium alginate, place it in a glass vessel, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0047] 4. the calcium chloride of 2 grams is weighed, dissolves with water for injection, prepares the calcium chloride solution of 1% by...

Embodiment 2

[0057] Preparation of sodium alginate microspheres containing sodium morrhuate

[0058] 1. Preparations before packing:

[0059] ① Handling of glassware:

[0060] Air-dry the cleaned glassware, put it in a high-temperature oven and bake at 280 degrees Celsius for 3 hours (sterilize and remove heat source);

[0061] ②Preparation of sodium morrhuate medicinal solution for anti-angioma drug:

[0062] Take by weighing 10 grams of commercially available sodium morrhuate, place in the above-mentioned glass vessel, add water to dissolve, and obtain sodium morrhuate drug solution;

[0063] ③ Preparation of sodium alginate solution:

[0064] Weigh 50 grams of commercially available sodium alginate, place it in a glass vessel, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0065] 4. get 12 grams of barium chloride, prepare the barium chloride solution of 12% by weight;

[0066] ⑤ Prepare liquid p...

Embodiment 3

[0075] Preparation of Sodium Alginate Microspheres Containing Urea

[0076] 1. Preparations before packing:

[0077] ① Handling of glassware:

[0078] Air-dry the cleaned glassware, put it in a high-temperature oven and bake at 280 degrees Celsius for 3 hours (sterilize and remove heat source);

[0079] ②Preparation of urea solution for anti-angioma drug:

[0080] Take by weighing 10 grams of commercially available urea, place in the above-mentioned glass vessel, add water to dissolve, and obtain the urea drug solution;

[0081] ③ Preparation of sodium alginate solution:

[0082] Weigh 600 grams of commercially available sodium alginate, place it in a glass container, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0083] 4. get 6 grams of calcium chloride, prepare the calcium chloride solution of 6% by weight;

[0084] ⑤ Prepare vegetable oil as a preservation solution;

[0085] 6. Mix...

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Abstract

The invention discloses a sodium alginate microballoon vein suppository containing hemangioma-resisting medicant, a preparation method and an application thereof. The sodium alginate microballoon vein suppository comprises carrier sodium alginate and hemangioma-resisting medicant; the sodium alginate covers the hemangioma-resisting medicant; the weight ratio of the sodium alginate to the hemangioma-resisting medicant is 5:1-60:1; and the hemangioma-resisting medicant is pingyangmycin, sodium morrhuate, carbamide or bleocin. The raw materials used in the invention have favorable mechanical strength, biocompatibility, biological degradability and stability, have no organic solvent, and are basically harmless to functions of hemopoietic system and immune system, thereby suppository can be industrially produced.

Description

technical field [0001] The present invention relates to sodium alginate microsphere vascular embolism containing medicine and its preparation method and application, especially sodium alginate microsphere vascular embolism containing antiangioma drug (pingyangmycin, urea, sodium morrhuate, bleomycin) And its preparation method and application. Background technique [0002] Hemangioma is the most common benign tumor in humans, and hemangioma of the liver is one of the most common benign tumors of the liver. It is more common in adults, and women are more common than men. Those with small tumors are asymptomatic in the early stage and are often found during physical examination. However, with the expansion of the lesion, clinically, abdominal pain, abdominal distension, hepatomegaly, abdominal mass, gastrointestinal Compression and other symptoms, and there is a risk of spontaneous and traumatic rupture and bleeding. Once the hemangioma ruptures, its hemorrhage can be fatal....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/36A61K38/14A61K31/21A61K31/17A61P35/00A61J3/00A61L31/14A61K31/20A61K31/201
CPCA61K31/7056A61K31/20A61K31/17A61P35/00
Inventor 李新建鲁格洪宏
Owner BEIJING SHENGYIYAO SCI & TECH DEV
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