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Needle amperometric determination type glucose sensor for subcutaneous tissue real-time monitoring and manufacturing method thereof

A glucose sensor and real-time monitoring technology, which is applied in the directions of sensors, applications, diagnostic recording/measurement, etc., can solve the problems of poor biocompatibility and inability to provide blood glucose values ​​for users, achieve good stability, shorten response time, increase glucose and The effect of oxygen concentration

Active Publication Date: 2009-09-16
HUZHOU MEIQI MEDICAL EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the deficiency that the glucose sensor in the prior art has poor biocompatibility and cannot provide users with the current blood glucose level in real time, and provides a needle-shaped amperometric glucose sensor with good biocompatibility for real-time monitoring of subcutaneous tissue and its Production Method

Method used

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  • Needle amperometric determination type glucose sensor for subcutaneous tissue real-time monitoring and manufacturing method thereof
  • Needle amperometric determination type glucose sensor for subcutaneous tissue real-time monitoring and manufacturing method thereof
  • Needle amperometric determination type glucose sensor for subcutaneous tissue real-time monitoring and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1, needle-shaped amperometric glucose sensor for real-time monitoring of subcutaneous tissue, such as figure 1 , 2 , 3, including a needle-shaped reference electrode 2 and at least one needle-shaped working electrode 1, the working electrode 1 includes a conductive layer 8 and an enzyme film layer 6, and is characterized in that: the working electrode 1 also includes a polymer material The inner membrane layer 7 and the polymer material controlled diffusion layer 5 are covered sequentially from the inside to the outside by the conductive layer 8 , the polymer material inner membrane layer 7 , the enzyme membrane layer 6 and the polymer material controlled diffusion layer 5 .

[0060] The working electrode 1 and the reference electrode 2 can pass through the plastic base 3 , and the fixed wireless transmitting device is embedded in the plastic base 3 and connected with the working electrode 1 and the reference electrode 2 .

[0061] In this example:

[0062]...

Embodiment 2

[0078] Example 2, a needle-shaped amperometric glucose sensor for real-time monitoring of subcutaneous tissue, has the same general structure and experimental conditions, and the only differences are as follows.

[0079] The noble metal layer 81 of the conductive layer 8 is made of platinum;

[0080] The material of the polymer inner film layer 7 is epoxy resin;

[0081] Eight identical glucose sensors (ie, sensors 9 through 16) were also prepared with the following thickness R.

[0082]

parameter

Metal substrate 83 metal over

Transition layer 82 precious metal layer

81 Polymer Materials

Intima layer 7

Enzyme layer 6 Thickness (R) R7 = 250μμm R6=1μm R5=3μm R4=3μm R3=1μm

parameter Polymer material control

Diffusion layer 5 Hydrophilic

Hydration Layer 4 metal substrate

122

Silver layer 121 Polymer Materials

Adventitia 10 Thickness (R) R2 = 10μm R1=6μm R11 = 250...

Embodiment 3

[0088] Embodiment 3, the method for making the needle-shaped amperometric glucose sensor for real-time monitoring of subcutaneous tissue in Embodiment 1: the glucose sensor has two working electrodes 1 and a reference electrode 2, and the working electrode 1 and the reference electrode 2 can be fixed on a plastic On the base 3, the working electrode 1 and the reference electrode 2 form a loop through wires.

[0089]The conductive layer 8 of the working electrode 1 is composed of a metal base 83 , a metal transition layer 82 , and a noble metal layer 81 sequentially from inside to outside.

[0090] The metal transition layer 82 is attached to the surface of the metal base 83 by magnetron sputtering;

[0091] The noble metal layer 81 is attached to the surface of the metal transition layer 82 by electroplating;

[0092] The surface of the conductive layer 8 is activated by an oxygen ion etching method.

[0093] The polymer material inner film layer 7 is combined on the surface...

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Abstract

The invention discloses a needle amperometric determination type glucose sensor for subcutaneous tissue real-time monitoring and manufacturing method thereof. The sensor comprises a needle reference electrode (2) and at least one needle working electrode (1) including a conducting layer (8) and an enzyme membrane layer (6), and is characterized in that the working electrode (1) further comprises a polymer material inner membrane layer (7) and a polymer material control diffusion layer (5), and the conducting layer (8), the polymer material inner membrane layer (7), the enzyme membrane layer (6) and the polymer material control diffusion layer (5) are coated in turn from inner to outside. According to the manufacturing method in the invention, the glucose sensor has good stability, high flexibility, wide linear range of output current and glucose concentration, short response time, continuous real-time monitoring, good fastness and stability of enzyme bonding, high flexibility, selectivity and repeatability.

Description

technical field [0001] The invention relates to a needle-shaped amperometric glucose sensor for real-time monitoring of subcutaneous tissue and a manufacturing method thereof, in particular to a needle for real-time monitoring of subcutaneous tissue based on a needle-shaped reference electrode and glucose oxidase fixed in the working electrode. Shaped amperometric glucose sensor and manufacturing method thereof. Background technique [0002] The first type of traditional blood glucose monitor is an invasive measuring instrument, and its method is to take blood from a fingertip for measurement and inspection. The second category is non-invasive blood glucose detectors, including subcutaneous interstitial fluid glucose detectors and spectral analysis blood glucose meters. The third category is the continuous blood glucose monitor. The portable CGMS manufactured by MiniMed has been approved by the FDA for continuous blood glucose measurement. The instrument adds a glucose sen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1486
Inventor 程荣恩章峰李熊飞
Owner HUZHOU MEIQI MEDICAL EQUIP CO LTD
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