Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of mulberroside in preparing medicament for inhibiting uric acid reabsorption transporter

A mulberry glycoside and reabsorption technology is applied in the application field of mulberry glycoside in the preparation of a drug for inhibiting uric acid reabsorption transporter, and achieves the effects of clear action mechanism, good safety and clear regulatory effect.

Inactive Publication Date: 2009-08-12
ZHEJIANG CONBA PHARMA +1
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the use of the compound monomer mulberryside in the preparation of drugs that inhibit uric acid reabsorption transporters

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of mulberroside in preparing medicament for inhibiting uric acid reabsorption transporter
  • Application of mulberroside in preparing medicament for inhibiting uric acid reabsorption transporter
  • Application of mulberroside in preparing medicament for inhibiting uric acid reabsorption transporter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The following examples can enable those skilled in the art to understand the present invention more comprehensively, but do not limit the present invention in any way.

[0026] Inhibitory modulation of the uric acid reabsorption transporter URAT1 by the monomeric compound mulbaritin.

[0027] Experimental animals: Kunming mice, 24±2g, male.

[0028] Drug preparation: the natural product sangbaritin containing 98%-100% by weight is evenly dispersed in normal saline for intragastric administration, with a low dose of 10 mg / kg and a high dose of 40 mg / kg.

[0029] Experimental materials: HPD-600 macroporous adsorption resin, Trizol Reagment (Invigen), chloroform, isopropanol, absolute ethanol, DEPC, M-MLV reverse transcriptase, PCR kit, RIPA lysate, uric acid kit, Creatinine Kit.

[0030] Experimental equipment: high-speed refrigerated centrifuge, high-speed homogenizer, Bio-rad vertical electrophoresis tank, MBI-PCR instrument, horizontal electrophoresis tank, etc.

[00...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a novel application of a mulberroside-A compound in the preparation of drugs for inhibiting uric acid re-absorption transporters, and a combination with the active component being the mulberroside-A compound for preparing the drugs for inhibiting the uric acid re-absorption transporters, so that the mulberroside-A compound with the chemical structure being 3-[2-[4-(Beta-D-glucopyranosyl-oxygen-2-hydroxyphenyl)]-(E)-ethenyl]-5-hydroxyphenyl-Beta-D-glucopyranoside is applicable in the preparation of the drugs for inhibiting the uric acid re-absorption transporters. The mulberroside-A can be either extracted from plants, traditional Chinese medicinal materials and traditional Chinese medicinal decoction pieces containing the mulberroside-A, or obtained through chemical synthesis. The drug preparation for inhibiting the uric acid re-absorption transporters can be either prepared separately from the mulberroside-A compound as the effective component or combined with pharmaceutically acceptable excipient, and further prepared into the drug forms of mulberroside-A, such as oral liquid, capsules, tablets, granules, targeting preparations and the like on the basis of the conventional preparation method.

Description

Technical field: [0001] The present invention relates to the new use of stilbene glycoside monomer compound Mulberroside A (MA for short), in particular to the new use of Mulberroside in the preparation of uric acid reabsorption transporter drugs, and using the compound as an active Composition of ingredients for the preparation of drugs inhibiting uric acid reabsorption transporters. Background technique: [0002] In recent years, a large number of epidemiological studies at home and abroad have shown that the prevalence of hyperuricemia / gout is increasing year by year. Hyperuricemia not only induces gouty arthritis, urolithiasis, and uric acid nephropathy, but also increases blood uric acid levels. Hyperuricemia is closely related to abnormal lipid metabolism, obesity and other diseases. Hyperuricemia / gout has become an important disease that threatens human health. Decreased excretion and / or increased production of uric acid is the main cause of primary hyperuricemia. P...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/7034A61P43/00A61P19/06
Inventor 胡季强孔令东胡林水王彩萍黄正标张宪叶剑锋王星
Owner ZHEJIANG CONBA PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com