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Method and composition for protection against radiation

A radiotherapy, tumor technology, applied in drug combinations, pharmaceutical formulations, peptide/protein components, etc., can solve problems such as dry mouth and permanent disability

Inactive Publication Date: 2009-07-08
BIO CANCER TREATMENT INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Many times, although the cancer is cured, the dry mouth caused by the treatment has become a permanent disability

Method used

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  • Method and composition for protection against radiation
  • Method and composition for protection against radiation
  • Method and composition for protection against radiation

Examples

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comparative example 1，2 and 3

[0041] Comparing Cases 1, 2 and 3, HCC cell death associated with PEGylated recombinant human arginase I was cell line dependent. Hep3B cells arrest cell cycle in G0 / G1 Phase at low concentration of PEGylated recombinant human arginase I, and arrest cell cycle in G2 / M Phase at higher concentration. However, in PLC / PRF / 5 cells, PEGylated recombinant human arginase I mainly caused cells to arrest cell cycle in S Phase, and ordered cells to enter apoptosis at high concentrations. During the G1 phase cells make proteins in preparation for cell division. S Phase normally lasts for 18 to 30 hours. G0 phase is the rest period, the cell has not yet started to divide, and only when the cell receives the replication information does it enter the G1 phase. It has been shown that most tumor cells such as Hep3B cells and PLC / PRF / 5 cells have a defective "R" checkpoint and ignore cells entering the cell cycle at low or no arginine concentrations. Therefore tumor cells are more affected b...

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Abstract

Methods are described for using an arginine depleting agent such as arginase and derivatives thereof, which reduce physiological arginine levels, as radioprotectants to protect normal mammalian cells from DNA damage caused by ionizing radiation. Treatment can result in the protection of normal tissues in cancer patients undergoing radiotherapy and in protection from the hazardous effects of exposure to radiological dispersal devices or occupational and environmental ionizing radiation.

Description

technical field [0001] The present invention relates to the use of arginase and other arginine degrading agents to protect normal cells from radiation damage, in particular to reduce symptoms during or after radiation therapy for the treatment of tumors. Background of the invention [0002] Radiation therapy is the use of high-energy rays or particles to kill cancer cells. Radiation therapy works because the ionizing radiation of radiation therapy destroys the ability of cancer cells to replicate. Patients may receive radiation therapy alone or in combination with other cancer treatments such as chemotherapy and / or surgery. [0003] Radiation therapy destroys the normal tissue surrounding the tumor, causing many unwanted side effects. These side effects are particularly profound for radiation therapy used to treat cancers of the esophagus, head and neck, lung, and rectum, as a large amount of accompanying tumor nearby tissue is also destroyed. In many cases, the side effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/43
CPCA61K38/50A61P35/04A61P39/00A61P43/00
Inventor 郑宁民
Owner BIO CANCER TREATMENT INT
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