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Application of franchet groundcherry calyx or fruit saponin in preparing medicament and health product for treating diabetes

A technology of bromide and saponin, which is applied in the application field of bromide saponin in the preparation of diabetes medicine and health products, to achieve significant hypoglycemic effect, simple extraction process, and the effect of improving the body's immunity

Active Publication Date: 2009-07-08
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemical prescription drugs account for the absolute dominant share of hypoglycemic products. Although the effect is obvious, the side effects such as drug resistance, drug resistance, liver and kidney damage caused by long-term medication make diabetic patients feel more painful

Method used

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  • Application of franchet groundcherry calyx or fruit saponin in preparing medicament and health product for treating diabetes
  • Application of franchet groundcherry calyx or fruit saponin in preparing medicament and health product for treating diabetes
  • Application of franchet groundcherry calyx or fruit saponin in preparing medicament and health product for treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Preparation of calyxin from Jindenglong:

[0015] Step 1: Soak 200g of the persistent calyx of the brocade lantern fruit in 1500ml of 60-70% ethanol solution overnight, repeat the reflux extraction for 3 times, each time at 60°C for 2 hours, and combine the filtrate after filtration; after the filtrate is centrifuged, rotate the evaporation to concentrate the filtrate to about 200ml; the filtrate was repeatedly extracted with water-saturated n-butanol solution, and after the n-butanol layers were combined, they were rotated and evaporated to obtain an extract-like substance; the precipitate was dissolved with a small amount of methanol, and 5 times of ethyl ether was added to wash repeatedly until the supernatant was colorless. Discard the supernatant; dry the precipitate in a vacuum oven to obtain about 1.5 g of crude saponin.

[0016] Step 2 Dissolve 200 mg of saponins in 20 ml of distilled water, and load the sample on the prepared D-101 macroporous adsorption resin ...

Embodiment 2

[0018] Preparation of calyxin from Jindenglong:

[0019] Step 1: Soak 200g of the persistent calyx of the broccoli fruit in 1500ml of 80% methanol solution overnight, repeat the reflux extraction for 3 times, each time at 50°C for 1 hour, and combine the filtrate after filtration; after the filtrate is centrifuged, rotate the evaporation to concentrate the filtrate to about 200ml; the filtrate was repeatedly extracted with water-saturated n-butanol solution, and after the n-butanol layers were combined, they were rotated to evaporate to obtain an extract-like substance; the precipitate was dissolved with a small amount of methanol, and 4 times of ethyl ether was added to wash repeatedly until the supernatant was colorless, discarded Clear; dry the precipitate in a vacuum oven to obtain about 1.5 g of crude saponin.

[0020] Step 2 Dissolve 200 mg of saponins in 20 ml of distilled water, and load the sample on the prepared D-101 macroporous adsorption resin column; after elutio...

Embodiment 3

[0022] Preparation of calyxin from Jindenglong:

[0023] Step 1: Soak 200g of the persistent calyx of the brocade lantern fruit in 1500ml of 70% methanol solution overnight, repeat the reflux extraction for 3 times, each time at 70°C for 4 hours, and combine the filtrate after filtration; after the filtrate is centrifuged, rotate the evaporation to concentrate the filtrate to about 200ml; the filtrate was repeatedly extracted with water-saturated n-butanol solution, and after the n-butanol layers were combined, they were rotary evaporated to obtain an extract-like substance; the precipitate was dissolved with a small amount of methanol, and 6 times of ethyl ether was added to wash repeatedly until the supernatant was colorless, discarded Clear; dry the precipitate in a vacuum oven to obtain about 1.5 g of crude saponin.

[0024] Step 2 Dissolve 200 mg of saponins in 20 ml of distilled water, and load the sample on the prepared D-101 macroporous adsorption resin column; after e...

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Abstract

The invention belongs to an application in the pharmaceutical field, in particular to the application of wintercherry fruit or calyx persistent calyx saponin in preparing medicines and health products for curing diabetes. In the invention, dry wintercherry fruit or calyx goes through the processes of reflux extraction, concentration, extraction, washing, drying and the like, thus obtaining a crude product of saponin. Through a D-101 type macroporous absorbent resin column, distilled water is adopted for elution, then ethanol solution is adopted for elution, finally the wintercherry fruit or calyx persistent calyx saponin is obtained after the processes of rotary evaporation and lyophilization, etc. The extraction process is simple and the cost is low, the source of materials is wide, adaptability thereof is strong and the materials are extremely easy to be planted manually in a large scale. The product of the invention has the functions of markedly lowering blood sugar level and strengthening immunity, therefore, the product can be applied as the medicine for curing patients suffering from diabetes and as health products for preventing diabetes and improving organism immunity.

Description

technical field [0001] The invention belongs to the application in the field of pharmacy, and in particular relates to the application of calyxin in the preparation of medicines for treating diabetes and health care products. Background technique [0002] With social progress and rapid economic development, the incidence of diabetes is increasing day by day, and young and middle-aged people join the "army" of diabetes at twice the rate of the elderly. Therefore, drugs related to the prevention and treatment of diabetes have become the focus and development trend of international and domestic research. [0003] At present, the hypoglycemic market in my country is dominated by western medicine, accounting for about 73.68% of the entire market share; supplemented by Chinese patent medicine, accounting for about 24.7%. Chemical prescription drugs account for the absolute dominant share of hypoglycemic products. Although the effect is obvious, the side effects such as drug resis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P3/10A61K131/00
Inventor 王桂云刘雅丽
Owner NORTHEAST NORMAL UNIVERSITY
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