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Preparation method of polyporous material for biological medicine tissue engineering scaffold

A technology of tissue engineering scaffolds and porous materials, applied in biochemical equipment and methods, scaffolds, microorganisms, etc., can solve the problems of difficult preparation of bulk porous scaffolds, pore-forming agent residues, unstable processes, etc., and achieve the same processing effect , the effect is consistent, the effect of the procedure is simple

Inactive Publication Date: 2009-06-17
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for preparing porous materials for biomedical tissue engineering scaffolds, which uses mechanical processing to prepare porous tissue engineering scaffolds, and solves the problems of high preparation costs, unstable processes, residual pore-forming agents, and scaffold strength in traditional technologies. Low, and difficult to prepare bulky porous scaffolds and other defects

Method used

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  • Preparation method of polyporous material for biological medicine tissue engineering scaffold
  • Preparation method of polyporous material for biological medicine tissue engineering scaffold
  • Preparation method of polyporous material for biological medicine tissue engineering scaffold

Examples

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Embodiment 1

[0025] Prepared by laser drilling technology such as figure 1 The shown porous magnesium tissue engineering scaffold has a size of 8×8×8mm 3 , with a pore size of 500 μm and a porosity of 48%. figure 2 As shown, the porous structure can be surface treated, and the surface treatment coating has grown into the interior of the porous structure.

Embodiment 2

[0027] The difference from Example 1 is: the preparation of porous titanium alloy tissue engineering support (the grade of titanium alloy in this embodiment is Ti 6 Al 4 V), its size is 8×8×8mm 3 , with a pore size of 300 μm and a porosity of 60%.

Embodiment 3

[0029] The difference from Example 1 is: the porous silicon carbide tissue engineering scaffold is prepared, and its size is 8×8×8mm 3 , with a pore size of 400 μm and a porosity of 62%.

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Abstract

The invention relates to the technical field of biomaterials, is particularly suitable for the field of preparation of biomedical tissue engineering support materials, in particular to a method for preparing porous materials used by a tissue engineering support. The method is to adopt mechanical processing technology to prepare the porous materials, to use the porous materials in the tissue engineering support, and to provide a three-dimensional space for adhesion, growth and so on of cells. The mechanical processing method comprises laser processing technology and digital control drilling processing technology. The porous materials prepared by the mechanical processing method have a permeable porous structure, wherein the porosity is between 5 and 99 percent, and the aperture is between 50 and 900 mu m. The method can prepare various metallic materials, wherein the laser drilling technology can also prepare porous polymer materials, ceramic materials, composite materials and so on and have wide application scope.

Description

technical field [0001] The invention relates to the technical field of biomaterials, and is particularly suitable for the field of preparation of scaffold materials for biomedical tissue engineering, in particular to a method for preparing porous materials for tissue engineering scaffolds. Background technique [0002] Tissue Engineering is an emerging medical technology emerging in recent years. It applies the principles and technologies of life science and engineering to correctly understand the relationship between the tissue structure and function of mammals in both normal and pathological states. Research and development of biological substitutes for repairing, maintaining, and promoting the functions and shapes of various tissues or organs of the human body after damage has received great attention. The core of tissue engineering is to establish a three-dimensional space complex composed of cells and biomaterials. The basic principle and method are to adsorb normal tis...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/02A61L31/04C12N5/00A61F2/82
Inventor 杨柯谭丽丽张炳春郑丰耿芳龚明明
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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