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Sea cucumber peptide micro-pills and preparation method thereof

A technology of peptide pellets and sea cucumber peptides, which is applied in the field of medicine and food, can solve the problems of low bioavailability, gastric mucosal irritation, and long disintegration time, and achieve high bioavailability, good effectiveness, and reduced total dosage. Effect

Inactive Publication Date: 2009-06-17
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently developed sea cucumber peptide products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; they disintegrate at a certain point in the body, which is irritating to the gastric mucosa; the bioavailability is low, etc. shortcoming

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take the following ingredients for the recipe

[0032] Sea cucumber peptide 28g starch 69g Hydroxypropylmethylcellulose 3g

[0033] Prepare pellet formulations as follows:

[0034] (1) Take the sea cucumber peptide in the amount of the above formula and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0035] (2) hydroxypropyl methylcellulose is dissolved in 75% ethanol solution;

[0036] (3) The extrusion-spheronization method is used to make pellets.

Embodiment 2

[0038] Take the following ingredients for the recipe

[0039] Sea cucumber peptide 53g starch 43g Polyvinylpyrrolidone 4g

[0040] Prepare pellet formulations as follows:

[0041] (1) Take the sea cucumber peptide in the amount of the above formula and add it to starch, pulverize it to a micronized level with a ball mill, and mix well;

[0042] (2) the adhesive polyvinylpyrrolidone is dissolved in water;

[0043] (3) Micro-pills were made by pan-pill method.

Embodiment 3

[0045] Take the following ingredients for the recipe

[0046] Sea cucumber peptide 72g Crystalline Cellulose 26g Hydroxypropylmethylcellulose 2g

[0047]Prepare pellet formulations as follows:

[0048] (1) Take the sea cucumber peptide of the above-mentioned formula amount and add the crystal cellulose, pulverize it to a micronization level with a ball mill, and mix well;

[0049] (2) hydroxypropyl methylcellulose is dissolved in an appropriate amount of 70% ethanol;

[0050] (3) The centrifugal-fluidized pelletizing method is used to make pellets.

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PUM

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Abstract

The invention discloses a pellet formulation of sea cucumber peptide which is prepared by sea cucumber peptide and pharmaceutical excipients, wherein the pharmaceutical excipients are excipient and adhesive. In the pellet formulation, the weight percentage of the sea cucumber peptide is 2-85%, the weight percentage of the excipient is 20-80%, and the weight percentage of the adhesive is 1-5%. The inventive pellet preparation has high dissolution rate and bioavailability, easy and convenient preparation method, and easy operation.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made of sea cucumber peptide and a preparation method thereof. Background technique: [0002] Sea cucumber is not only a delicacy on the banquet, but also a treasure to nourish the human body. It contains more than 50 kinds of nutrients. Sea cucumber peptides are extracted from fresh sea cucumbers using modern biological extraction and separation technology. It retains the active substances rich in sea cucumber walls and viscera—sea cucumber acidic mucopolysaccharides, sea cucumber saponins, proteins, etc. to the greatest extent. Sea cucumber peptides not only contain a large number of polypeptides that are important to the human body, but also rich in amino acids, vitamins, calcium, phosphorus, iron, iodine, vanadium and other nutrients, of which the protein content is more than 55%, which is a high-protein, Low-fat, low-cholesterol high-energy nourishing fo...

Claims

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Application Information

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IPC IPC(8): A61K35/56A61K38/02A61K9/16A61K47/36A61K47/38A61P1/14A23L1/29A61K35/616
Inventor 刘亚楠
Owner JF PHARMALAND TECH DEV
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