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Microchannel for separating blood plasma

A plasma separation and micro-channel technology, which is applied in the field of flow channel structure of blood cells and plasma, can solve problems such as difficult separation of blood, and achieve the effect of simple plasma separation

Inactive Publication Date: 2009-06-10
KYOTO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even if such a structure is miniaturized in this state, it is difficult to efficiently separate a small amount of blood

Method used

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  • Microchannel for separating blood plasma
  • Microchannel for separating blood plasma
  • Microchannel for separating blood plasma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] use Figure 1 ~ Figure 4 A microchip for blood testing (hereinafter also simply referred to as "microchip") according to Example 1 of the present invention will be described.

[0052] refer to figure 1 The basic structure of the microchip 10 will be described. figure 1 (a) is a top perspective view, figure 1 (b) is along figure 1 The sectional view cut off by b-b in (a).

[0053] Such as figure 1 As shown in (a), the microchip 10 has flow paths 11 , 13 , and 14 formed in a substantially Y shape substantially parallel to the extending direction of the substrate body 10 a inside the substrate body 10 a serving as the main body of the microchip 10 . That is, on the side of the one end 11b of the separation flow path 11, the first branch flow path 13 and the second branch flow path are branched from the communication ports 13a, 14a formed adjacently in the thickness direction perpendicular to the direction in which the substrate body 10a extends. 14.

[0054] A ...

Embodiment 2

[0094] use Figure 5 ~ Figure 8 The microchip for blood tests (hereinafter also simply referred to as "microchip") 100 of Example 2 will be described.

[0095] The microchip 100 of the second embodiment has substantially the same configuration as the microchip 10 of the first embodiment. Figure 5 It is (a) top perspective view, (b) side perspective view of the microchip 100. FIG. Figure 6 It is (a) plan view and (b) side view of upper substrate 130 . Figure 7 It is (a) plan view and (b) side view of the lower substrate 120 .

[0096] Such as Figure 5 ~ Figure 7 As shown, the microchip 100 is the same as in Example 1. A thin plate 140 for forming a partition structure is sandwiched between substrates 120, 130 formed with grooves 122, 124 and grooves 132, 134 as Y-shaped flow paths, and separated. The flow path 110 is branched into a first branch flow path 113 and a second branch flow path 114 .

[0097] Unlike Example 1, the groove 134 serving as the separation channel...

Embodiment 3

[0110] refer to Figure 9 ~ Figure 11The microchip array for blood tests (hereinafter also simply referred to as "microchip array") 200 of Example 3 will be described. Figure 9 is a top perspective view of microchip array 200 . Figure 10 is along Figure 9 A cross-sectional view cut from A-A in . Figure 11 is along Figure 9 The cut-off view of B-B in .

[0111] The microchip array 200 of the third embodiment has the same configuration as that of the first and second embodiments. Hereinafter, differences from Embodiment 1 and Embodiment 2 will be mainly described.

[0112] Such as Figure 9 ~ Figure 11 As shown, in the microchip array 200 , two sets of flow path structures 220 are formed on a substrate body 210 formed by bonding a pair of substrates 212 and 214 with parallel planes. For example, glass substrates are used in the substrates 212 and 214, and CH 3 The flow path structure 220 is formed by plasma etching or ion beam etching with a fluorine-based gas such ...

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Abstract

It is intended to provide a microchannel for separating blood plasma whereby blood plasma can be conveniently separated on a microchip. A microchannel comprising: a substrate body (10a); a separation channel (11) which is formed within the substrate body (10a) and extended in the direction parallel to the longitudinal direction of the substrate body (10a); at least two (first and second) connection ports (13a, 14a) which are formed at one end of the separation channel (11) close to the thickness direction perpendicular to the longitudinal direction of the substrate body (10a); and first and second branch channels (13, 14) which are formed within the substrate body (10a) and connected respectively to the first and second connection ports (13a, 14a). In the state where the substrate body (10a) is extended perpendicular to the direction of gravitational force, a blood sample containing blood cells and plasma is flown from one end (11a) side of the separation channel (11). Before the blood sample attains the other end (11b) of the separation channel (11), the blood cells in the blood sample settle out. The blood cells having settled out are then introduced into the branch channel (14)that is located lower in the direction of gravitational force between the first and second branch channels. On the other hand, the major portion of the blood plasma is introduced into the other branch channel (13) located upper in the direction of gravitational force.

Description

technical field [0001] The present invention relates to a microchannel for plasma separation, and more specifically, to a channel structure for separating blood cells and plasma in a blood sample in a microchip for blood test or the like. Background technique [0002] Blood tests are the most common means used to diagnose health. In recent years, technology development for blood tests on microchips has been carried out, and through the single-chip packaging of such a chip, it can be expected to reduce the pain of blood drawing as the required blood volume decreases, miniaturize the device, and improve the quality of care through care. Speed ​​up the inspection of station inspection, reduce the cost of inspection by reducing the amount of reagents, etc. [0003] However, the inspection items of the blood test are basically related to the soluble components in the blood, and blood cells, which account for about 50% of the volume in the blood, become obstructive components in ...

Claims

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Application Information

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IPC IPC(8): G01N33/48G01N37/00
CPCB01L2300/0864G01N33/491B01L3/502761B01L2300/0809B01L2200/0668B01L2400/086B01L3/502753B01L2400/0457B01L2200/0652Y10T137/2082Y10T137/212Y10T137/218
Inventor 小寺秀俊鹫津正夫小穴英广
Owner KYOTO UNIV
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