Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Metronidazole stomatocace double-layer paster and preparation method thereof

A technology for oral ulcers and metronidazole, applied in the field of metronidazole oral ulcer double-layer pasting tablets and its preparation, can solve the problems of ineffectiveness of aerobic bacteria and facultative anaerobic bacteria, so as to avoid slow release and alleviate Effects of pain reduction and systemic side effects

Inactive Publication Date: 2009-06-10
TIANJIN PACIFIC PHARMA
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Metronidazole: Metronidazole has a strong antibacterial effect on most anaerobic bacteria, but has no effect on aerobic bacteria and facultative anaerobes

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Metronidazole stomatocace double-layer paster and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of Metronidazole Double-layer Oral Adhesive Tablets (1000 Tablets)

[0033] Metronidazole 0.5g

[0034] Carbopol 3g

[0035] Xylitol 8.5g

[0036] Low-substituted hydroxypropyl cellulose 8g

[0037] Sodium Carboxymethyl Cellulose 17g

[0038] Magnesium stearate 0.2g

[0039] Talc powder 0.6g

[0040]Ethyl cellulose 0.5g

[0041] Red pigment 1mg

[0042] Preparation Process:

[0043] Pass the prescribed amount of metronidazole, xylitol, low-substituted hydroxypropyl cellulose, and sodium carboxymethyl cellulose through a 100-mesh sieve, mix well, granulate through a 30-mesh sieve, dry at 60°C, and Sieve through a 30-mesh sieve, add carbopol, magnesium stearate, and talcum powder passed through a 100-mesh sieve, mix well, and press into tablets with a flat punch with a diameter of 6 mm. Each tablet weighs about 40 mg, and contains amlexanox. 0.5 mg. Dissolve 0.8 g of ethyl cellulose with 95 ml of 95% ethanol, add 1 mg of pigment, spray evenly on the ...

Embodiment 2

[0050] Preparation of Metronidazole Double-layer Oral Adhesive Tablets (1000 Tablets)

[0051] Metronidazole 2g

[0052] Carbopol 3g

[0053] Xylitol 8.5g

[0054] Low-substituted hydroxypropyl cellulose 8g

[0055] Sodium Carboxymethyl Cellulose 17g

[0056] Magnesium stearate 0.2g

[0057] Talc powder 0.6g

[0058] Ethyl cellulose 1g

[0059] Red pigment 1.5mg

[0060] Preparation Process:

[0061] Pass the prescribed amount of metronidazole, xylitol, low-substituted hydroxypropyl cellulose, and sodium carboxymethyl cellulose through a 100-mesh sieve, mix well, granulate through a 30-mesh sieve, dry at 60°C, and Sieve through a 30-mesh sieve, add carbopol, magnesium stearate, and talcum powder passed through a 100-mesh sieve, mix thoroughly, and press into tablets with a flat punch with a diameter of 6 mm. Each tablet weighs about 42 mg and contains amlexanox. 2mg. Dissolve 0.8 g of ethyl cellulose with 95 ml of 95% ethanol, add 1.5 mg of pigment, spray evenly on t...

Embodiment 3

[0068] Preparation of Metronidazole Double-layer Oral Adhesive Tablets (1000 Tablets)

[0069] Metronidazole 5g

[0070] Carbopol 3g

[0071] Xylitol 8.5g

[0072] Low-substituted hydroxypropyl cellulose 8g

[0073] Sodium Carboxymethyl Cellulose 17g

[0074] Magnesium stearate 0.2g

[0075] Talc powder 0.6g

[0076] Ethylcellulose 1.5g

[0077] Yellow pigment 2mg

[0078] Preparation Process:

[0079] Pass the prescribed amount of metronidazole, xylitol, low-substituted hydroxypropyl cellulose, and sodium carboxymethyl cellulose through a 100-mesh sieve, mix well, granulate through a 30-mesh sieve, dry at 60°C, and Sieve through a 30-mesh sieve, add carbopol, magnesium stearate, and talcum powder passed through a 100-mesh sieve, mix thoroughly, and press into tablets with a flat punch with a diameter of 6 mm. Each tablet weighs about 45 mg and contains amlexanox. 5 mg. Dissolve 0.8 g of ethyl cellulose with 95 ml of 95% ethanol, add 2 mg of pigment, spray evenly on ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a metronidazole stomatocace patch and preparing method thereof, the oral cavity adhere patch is divided into two layers, one layer is an adhere layer containing amlexanox 0. 1-10 mg; the other layer is a protecting layer which is insoluble. According to the double-layer design, the dissolution of the medicament towards the opposite side of the oral mucosa and the bidirectional adhesion between the gingiva and oral mucosa of the patch can be reduced, the medicament can be infiltrated into ulcer surface and the uncomfortableness of the medicament in the oral cavity can be reduced. The double-layer oral cavity adhere patch is positioned on the focus position, has no simulation for the ulcer surface, has slow-release action for exerting medicament effect as long as 3-4 hours, can alleviate the pain caused by the ulcer for long time.

Description

technical field [0001] The invention relates to a medicine for treating oral diseases, in particular to a metronidazole oral ulcer double-layer pasting tablet and a preparation method thereof. technical background [0002] Recurrent aphthous ulcer is a kind of modal oral mucosa disease, and prevalence rate is generally considered to exceed 10% in the crowd, can occur in men and women, old and young, sees most with young and middle-aged. [0003] Recurrent aphtha is a kind of localized oral mucosal ulcer damage characterized by periodic recurrence, which can heal itself, and can occur in any part of the oral mucosa, most commonly seen on the lips, cheeks, and tongue, and can spread to the pharynx in severe cases mucous membranes. With the prolongation of the course of the disease, many patients have enlarged ulcer area and number, aggravated pain, prolonged healing period, and shortened interval, which affect eating and speaking. Oral ulcer is a common oral disease, manifes...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4164A61K9/70A61K47/38A61P1/02
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com