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Device for enhancing tissue glucose processing

A technology of glucose and blood glucose, which is applied in the fields of drug devices, medical preparations containing active ingredients, peptide/protein ingredients, etc., which can solve the problems of expensive and time-consuming

Active Publication Date: 2012-01-11
托马斯・T・奥基
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The only available method of measuring "free" insulin is expensive and time consuming, often taking days to obtain results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Conduct a study to evaluate long-term interrupted intravenous insulin therapy (CIIIT), also known as metabolic activation therapy (MAT), liver activation, pulsed intravenous insulin therapy (PIVIT), pulsed or pulsed insulin therapy (PIT) for type I diabetes (DM) Impact of the progression of diabetic nephropathy in patients. This 18-month multicenter prospective controlled study involved 49 type I diabetes patients with kidney disease who followed the Diabetes Control and Complications Trial (DCCT) intensive therapy (IT) Program. Among them, 26 patients formed the control group (C) and continued IT, while the other 23 patients formed the treatment group (T), which also received CIIIT every week in addition to IT. All patients who participated in the study went to the clinic every week for the 18 months, and were tested for glycohemoglobin HbAlc monthly, and 24-hour urine protein excretion and creatinine clearance (CrCl) were measured every 3 months. As expected, both gr...

Embodiment 2

[0047] A middle-aged woman with type I diabetes for more than 22 years suffered from polyneuropathy. She was in pain all over, so she couldn't walk or even wear nylon stockings. After receiving the treatment of the method of the present invention, her pain was reduced to the point where she could enjoy strenuous exercise such as roller skating.

Embodiment 3

[0049] A middle-aged woman with type I diabetes for more than 30 years has severe peripheral neuropathy, persistent pain in her lower knee, and difficulty sleeping at night. After receiving the treatment of the method of the present invention, she no longer took pain medicine and no longer had pain in her leg. She has been using this treatment for eight years.

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PUM

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Abstract

The present invention is a system for delivering insulin to a subject to improve impaired total body tissue glucose processing. The system delivers one or more pulses of insulin to the subject over a period of time accompanied by ingestion of glucose in the form of a carbohydrate containing meal. The number of pulses, the amount of insulin in each pulse, the interval between pulses and the amountof time to deliver each pulse to the subject are selected so that total body tissue processing of glucose is restored in the subject. In subjects whose total body tissue glucose processing has been restored, there is a subsequent fall in circulating blood glucose levels of 50 mg / dl or more primarily and directly as a result of improved total body tissue glucose processing.

Description

Invention field [0001] The present invention is a device used to deliver a series of insulin pulses to a patient over a period of time to improve glucose processing of damaged total body tissue. More specifically, the number of pulses, the amount of insulin in each pulse, the time interval between pulses, and the amount of time to deliver each pulse to the patient are selected so that the patient's body tissue glucose processing is restored. In patients whose whole body tissue glucose processing has been restored, the circulating blood glucose level subsequently drops by 50 mg / dl or more. This is mainly and directly due to the improved whole body tissue glucose processing restored to multiple tissues, including but not limited to liver and muscle , Heart, kidneys, eyes, brain, skin, gastrointestinal tract and nerves. Background of the invention [0002] Diabetic retinopathy is the main cause of blindness. Although early detection and major advances in laser therapy have had a s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/28A61B5/00
CPCA61B5/14532A61M2230/201A61K38/28A61M5/1723A61B5/4088
Inventor 托马斯·T·奥基
Owner 托马斯・T・奥基
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