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Device for enhancing tissue glucose processing

A technology of glucose and blood glucose, which is applied in the direction of pharmaceutical devices, medical preparations containing active ingredients, peptide/protein components, etc., can solve the problems of costly and time-consuming

Active Publication Date: 2009-05-27
托马斯・T・奥基
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The only available method of measuring "free" insulin is expensive and time consuming, often taking days to obtain results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Conduct a study to evaluate the effects of long-term interrupted intravenous insulin therapy (CIIIT), also known as metabolic activation therapy (MAT), liver activation, pulsatile intravenous insulin therapy (PIVIT), pulsatile or pulsatile insulin therapy (PIT) in type 1 diabetes Impact of progression of diabetic nephropathy in (DM) patients. This 18-month, multicenter, prospective, controlled study involved 49 patients with type 1 diabetes and kidney disease following the Diabetes Control and Complications Trial (DCCT) intensive therapy (IT) Program. Among them, 26 patients constituted the control group (C), which continued with IT, while the other 23 patients constituted the treatment group (T), which underwent weekly CIIIT in addition to IT. All patients participating in the study visited the clinic weekly during the 18-month period, had monthly glycohemoglobin (glycohemoglobin) HbAlc testing, and had 24-hour urinary protein excretion and creatinine clearance (CrCl)...

Embodiment 2

[0047] A middle-aged woman with type I diabetes for more than 22 years suffered from polyneuropathy. She was in pain all over her body, so painful that she couldn't walk or even wear nylon stockings. After she accepted the treatment of the method of the present invention, the pain was reduced to the point where she could enjoy strenuous exercise such as roller skating.

Embodiment 3

[0049] A middle-aged woman with type 1 diabetes for more than 30 years had severe peripheral neuropathy, persistent lower knee pain, and difficulty sleeping at night. After receiving the treatment of the method of the present invention, she no longer takes pain medicine, and her legs no longer have labor pains. She has been using this treatment for eight years.

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PUM

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Abstract

The present invention is a system for delivering insulin to a subject to improve impaired total body tissue glucose processing. The system delivers one or more pulses of insulin to the subject over a period of time accompanied by ingestion of glucose in the form of a carbohydrate containing meal. The number of pulses, the amount of insulin in each pulse, the interval between pulses and the amount of time to deliver each pulse to the subject are selected so that total body tissue processing of glucose is restored in the subject. In subjects whose total body tissue glucose processing has been restored, there is a subsequent fall in circulating blood glucose levels of 50 mg / dl or more primarily and directly as a result of improved total body tissue glucose processing.

Description

field of invention [0001] The present invention is a device for delivering a series of pulses of insulin to a patient over a period of time to improve glucose handling in impaired total body tissue. More specifically, the number of pulses, the amount of insulin in each pulse, the time interval between pulses, and the amount of time each pulse is delivered to the patient are selected such that the patient's systemic tissue glucose processing is restored. In patients whose whole-body tissue glucose handling has been restored, circulating blood glucose levels subsequently decline by 50 mg / dl or more, primarily and directly due to improved whole-body tissue glucose handling restored to multiple tissues, including but not limited to liver, muscle , heart, kidneys, eyes, brain, skin, gastrointestinal tract and nerves. Background of the invention [0002] Diabetic retinopathy is a leading cause of blindness. Although early detection and major advances in laser therapy have had a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/28A61B5/00
CPCA61B5/14532A61M2230/201A61K38/28A61M5/1723A61B5/4088
Inventor 托马斯·T·奥基
Owner 托马斯・T・奥基
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