Open type cyclic tubular microbial dialysis cultivation system

Abstract

An open circulating type tubular microbial dialysis culture system relates to an open circulating type tubular microbial dialysis culture apparatus system. The system comprises a sealed hollow cylindrical culture medium chamber, wherein a sealed hollow cylindrical microbial dialysis culture chamber is arranged in the culture medium chamber; the upper end and the lower end of the culture medium chamber are respectively connected with a culture medium storage chamber through communicating pipes, and peristaltic pumps are connected on connecting pipes in series; the upper end and the lower end of the microbial dialysis culture chamber are respectively connected with a culture liquid storage chamber through the communicating pipes, and the peristaltic pumps are connected on the connecting pipes in series; exhaust holes are respectively arranged at the upper ends of the culture medium chamber and the microbial dialysis culture chamber, and the exhaust holes are also respectively arranged at the upper ends of the culture medium storage chamber and the culture liquid storage chamber. The system changes a planar dialysis membrane to a tubular dialysis membrane, changes the non-circulating type dialysis culture to the circulating type dialysis culture and changes the single batch dialysis culture method to the open continuous multi-batch dialysis culture production method.

Description

technical field [0001] The invention relates to an open circulating tubular microbial dialysis cultivator system, in particular to special equipment suitable for the industrial production of obligate anaerobic and facultative anaerobic microbial dialysis cultivators. Background technique [0002] Microbial dialysis culture can not only significantly increase the cell concentration, but also obtain relatively purified cells and large molecular weight products. Since the 1950s, although there have been a large number of successful reports of experimental dialysis culture devices at home and abroad, the equipment that can be used for industrial production is rare. In 1985, due to the development and research of Clostridium botulinum dialysis culture vaccine, China obtained the utility model patent certificate (No. 1873 on October 9, 1985) issued by the China Intellectual Property Office. The use of this closed non-circulating dialysis incubator can increase the toxin productio...

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Problems solved by technology

Since the 1950s, although there have been a large number of successful reports of experimental dialysis culture devices at home and abroad, the equipment that can be used for industrial production is rare.

But the above-mentioned closed type non-circulation microbial dialysis culture device needs to be sterilized three times with saturated water steam for each batch of use, such as empty box sterilization, medium sterilization and elimination treatment sterilization, the loading and unloading process is very cumbersome, and The dialysis membrane needs to be replaced after each batch is used, which is not suitable for the requirements of industrial production

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