Method for extracting admantadine

Abstract

The invention discloses a method for extracting amantadine, which aims to provide a method for extracting amantadine by a chemical means. The method has the advantages of simple technological process, little needed equipment and energy consumption, high yield, high purity of obtained amantadine and good quality. The invention adopts a technical proposal that after bromoadamantane and urea react to form water-insoluble amantadine, the amantadine is extracted according to the following steps: A. excessive hydrochloric acid is added to resultant, and the amantadine reacts with the hydrochloric acid to form water-soluble amantadine hydrochloride; and B. water-insoluble impurities are filtered and removed; excessive sodium hydroxide solution is added to residual solution; the amantadine hydrochloride and sodium hydroxide react to form the water-insoluble amantadine again; and the amantadine is filtered out. Due to the technical proposal of the invention, the amantadine yield of the method is higher than that of the prior process by more than 8 percent, and the purity of the obtained amantadine is more than 60 percent.

Description

technical field [0001] The present invention relates to a method for extracting organic compounds, more specifically, relates to a method for extracting amantadine. Background technique [0002] Amantadine is mainly used to manufacture an antiviral drug—amantadine hydrochloride, which is an intermediate product in the production process of the drug, and is produced using bromoadamantane and urea as raw materials. The process flow for taking amantadine is shown in Figure 1. The specific production method is: after heating the reactor to 170°C, add bromoadamantane and urea into the reactor, and the two undergo an amination reaction to form a water-insoluble The amantadine, its reaction formula is: [0003] [0004] Bromoadamantane Urea Amantadine [0005] Because the reactant contains water-insoluble impurities, the generated amantadine and water-insoluble impurities bond together to reduce its purity. In order to remove these water-insoluble impurities, after the reactio...

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Problems solved by technology

There are several problems in the above-mentioned method for extracting amantadine by physical means: 1. the addition amount of sodium hydroxide solution is difficult to control, if the addition amount is small, amantadine cannot be completely distilled out, and the yield of reaction is low, generally at 40% — Between 50%; if the amount added is too large, foam will be generated during distillation, and the impurities will be distilled out together on the foam. The separation of amantadine and impurities is not complete, and the purity of amantadine obtained is low, generally at 40%— Between 50%, the product quality is not high; ②The method of distillation is used to purify amantadine, which requires distillation equipment, consumes a lot of energy, and has high production costs

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