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Antimicrobial lubricious coating

An antimicrobial agent, prepolymer technology, applied in the manufacture of the subject lubricant coating, hydrophilic polymer coating field, can solve the lubricant coating can not provide antimicrobial and antithrombotic compound pharmaceutically acceptable carrier And other issues

Inactive Publication Date: 2009-05-13
COVIDIEN LP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, lubricant coatings that provide susceptibility to infection and or prothrombin reactions for the introduction of foreign devices into various regions of the body do not provide pharmaceutically acceptable carriers for use as antimicrobial and antithrombotic compounds

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] An antimicrobial slip coating was prepared by mixing the following components in a mixing bucket at room temperature for approximately 1 hour until completely dissolved to form a completely clear solution.

[0054] components %(wt)

[0055] Ethanol 97.25

[0056] PvP 0.25

[0057] PHMB 1.5

[0058] Isocyanate-terminated prepolymers 1

[0059] will be given by Wound care film samples prepared from films were dip-coated in the above solutions for approximately 10 seconds. After dipping, excess coating was removed by using a non-lint wicking agent. The samples were then oven cured at about 55°C for about 35 minutes. The resulting coating was clear and colorless and had excellent adhesion.

Embodiment 2

[0061] An antimicrobial slip coating using phytochemicals was prepared by mixing the following components in a mixing bucket at room temperature for approximately 1 hour until fully dissolved to form a completely clear solution.

[0062] Component % (wt)

[0063] Ethanol 93.75

[0064] PvP 0.25

[0065] Myrtle Oil / Tea Tree Extract 5

[0066] Isocyanate-terminated prepolymers 1

[0067] will be given by Wound care film samples prepared from films were dip-coated in the above solutions for approximately 10 seconds. After dipping, excess coating was removed by using a non-lint wicking agent.

[0068] The film samples were then oven cured at about 55°C for about 35 minutes. The resulting coating was clear and colorless and had excellent adhesion.

Embodiment 3

[0070] A lubricious coating vehicle for medical devices comprising a silver salt was prepared by mixing the following components in a mixing tub at room temperature for about 60 minutes until completely dissolved to form a completely clear to pale yellow solution. The order of binding components is not critical due to the lack of covalent bonding of the silver salt to the urethane. Silver salt release is regulated by PVP ratio adjustment due to salt trapping / ion bonding. Suitable silver salts include: Giltech Powders 01-07 (this is a water soluble glass silver salt produced by Giltech Ltd.); AlphaSan RC2000 (this is a zirconium / phosphate crystal produced by Milliken Chemical); SSD (a sulfonamide from Kendall silver pyrimidine); and silver chloride (obtained from Fisher Scientific).

[0071] A specific example configured by SSD is as follows:

[0072] Component % (wt)

[0073] Ethanol 96.75

[0074] PvP 0.25

[0075] SSD 2

[0076] Isocyanate-terminated prepolymers 1

[...

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Abstract

The present disclosure provides lubricious antimicrobial coating vehicles for medical devices capable of reducing the coefficient of friction of such devices upon exposure thereof to moisture and imparting antimicrobial properties to said devices. The coating vehicle allows the introduction of a pharmacological additive having a release rate that is within acceptable pharmacokinetic criteria.

Description

[0001] Related Application Cross Reference [0002] This application is a continuation-in-part of U.S. Patent Application Serial No. 11 / 592,859 filed November 3, 2006, which in turn is a U.S. Patent Application filed October 23, 2003 Serial No. 10 / 691,853, a continuation of what is now U.S. Patent No. 7,141,246, U.S. Patent Application Serial No. 10 / 691,853 in turn is U.S. Application Serial No. 09 / 739,577 filed December 18, 2000, now U.S. Patent No. 6,645,483 is a continuation-in-part of US Application Serial No. 09 / 739,577 which in turn is a continuation-in-part of the now abandoned US Application Serial No. 09 / 168,031 filed October 7,1998. The entire content of each prior application and patent is hereby incorporated by reference. technical field [0003] The present disclosure relates to slippery coatings for medical devices, and more particularly, to hydrophilic polymer coatings that assist medical devices to become slippery when wet. The lubricant coatings of the prese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/14A61L15/50
CPCC08G2190/00C10M2217/06C10M2207/0215C10N2210/01C10M2217/028A61L29/16A61L29/049A61L2300/206A61L29/14C10M2217/04A61L2300/406A61L2300/416C08G18/10C10N2240/66A61L2300/104C10N2010/02C10N2040/50C08L75/04C08G18/282C10M105/10C10M133/00C10M169/04C10N2030/16
Inventor D·L·麦吉
Owner COVIDIEN LP
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