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Traditional Chinese medicine formulation for treating non-insulin dependent diabetes mellitus and preparation method and use thereof

A non-insulin-dependent, diabetic technology, applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as toxicity, safety hazards, non-compliance, etc., to achieve toxicity reduction, The effect of lowering triglyceride and cholesterol and reducing safety hazards

Inactive Publication Date: 2009-04-29
浙江省中药研究所有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main pharmacodynamic studies have shown that Tangke Soft Capsules has a significant effect on the treatment of type 2 diabetes, but animal experiments have shown that it has certain toxicity, which poses a safety hazard to clinical medication, and is not in line with our original intention of developing high efficiency and low toxicity

Method used

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  • Traditional Chinese medicine formulation for treating non-insulin dependent diabetes mellitus and preparation method and use thereof
  • Traditional Chinese medicine formulation for treating non-insulin dependent diabetes mellitus and preparation method and use thereof
  • Traditional Chinese medicine formulation for treating non-insulin dependent diabetes mellitus and preparation method and use thereof

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Effect test

preparation example Construction

[0022] The preparation method of the traditional Chinese medicine medicament comprises the following steps:

[0023] (1) Weigh the materials according to the percentage by mass of Schisandra chinensis 19-87% and Ligustrum lucidum 13-81%.

[0024] (2) Take Schisandra chinensis, crush it into coarse powder, pass through a 20-40 mesh sieve, and put it in a supercritical extraction tank for extraction. The process conditions are: extraction pressure 21-23Mpa, separation pressure 6-8Mpa, temperature 38-45°C, carbon dioxide flow rate 50-60kg / hr, extraction time about 3-5 hours. A yellow transparent oily extract with a yield of 11-15% was obtained, and its relative density was about 0.98 (measured at 20° C.). After testing, the mass content of volatile oil and lignans fat-soluble substances in the extract is 50-90%.

[0025] (3) Take Ligustrum lucidum, crush it into coarse powder, put it in a multi-functional extraction tank, add 95% ethanol for extraction, 3 to 5 times the amount ...

Embodiment 1

[0033]Weigh Schisandra chinensis 8.5kg and Ligustrum lucidum 1.5kg respectively. Schisandra chinensis is crushed into coarse powder, passed through a 20-40 mesh sieve, and placed in a supercritical extraction tank. The process conditions are: extraction pressure 23Mpa, separation pressure 8Mpa, temperature 44-45°C, carbon dioxide flow rate 50kg / hr, and extraction time about 3 hours. 980 g of a transparent oily extract were obtained with a relative density of 0.98 (measured at 20° C.). After testing, the total content of volatile components and lignans fat-soluble substances in the extract is 51.8%, which is ready for use. Separately take Ligustrum lucidum, crush it into coarse powder, put it in a multi-functional extraction tank, add 4500ml of 95% ethanol to extract, extract twice, each time for 0.5 hours, discard the dregs, combine the two extracts and concentrate under reduced pressure, Obtain 30g of the yellow-brown oily extract, after testing, the content of oleanolic aci...

Embodiment 2

[0035] Weigh Schisandra 2kg and Ligustrum lucidum 8kg respectively. Operation according to embodiment 1, supercritical process condition is: extraction pressure 21Mpa, separation pressure 8Mpa, temperature 43~45 ℃, carbon dioxide flow rate 60kg / hr, extraction time is about 5 hours, obtains the extract of 29g transparent oil, and its relative density is 0.98 (measured at 20°C). After testing, the total content of volatile components and lignans fat-soluble substances in the extract is 52.5%, which is ready for use. The process conditions of Ligustrum lucidum extract are: add 40000ml of 95% ethanol to extract, extract 3 times, each time for 1 hour, discard the dregs, combine the extracts for 3 times and concentrate under reduced pressure to obtain 1440g yellow-brown oily extract. According to the test, the content of oleanolic acid in the extract is 4.5%, and it is ready for use. The content is obtained according to the above extraction method; the viscosity of the capsule mat...

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Abstract

The invention discloses a traditional Chinese medicine medicament applied to treating non-insulin-dependent diabetes mellitus and a preparation method as well as an application thereof. The medicament is mainly made from the following components by mass percent: 19 percent to 87 percent of schisandra chinensis and 13 percent to 81 percent of ligustrum lucidum. The Chinese medicine medicament has significant effect on treating non-insulin-dependent diabetes mellitus and can reduce triglyceride and cholesterin, improve symptoms of hydrodipsia, polydipsia, hypodynamia, insomnia and the like of the patients. Adding ligustrum lucidum extract in the prescription not only enhances the function of glucose-lowering, but also reduces toxicity as well as the hidden danger of clinical medication.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating type 2 diabetes, namely non-insulin-dependent diabetes mellitus (NIDDM), a preparation method and application. Background technique [0002] Diabetes is a serious, chronic, non-communicable, lifelong disease. It can be caused by many kinds of etiology, and it can also be complicated by various diseases such as hypertension, coronary heart disease, cerebrovascular disease, nephropathy, retinopathy, and jaundice of the extremities. With social development, scientific and technological progress, improvement of living standards, changes in living patterns and social aging, the incidence of diabetes is increasing year by year at an astonishing rate in both developed and developing countries, and the mortality rate of diabetes in western countries is second only to Yu ranks third after malignant tumors and cardiovascu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K9/48A61K9/107A61K47/36A61P3/10
Inventor 杨苏蓓王溶溶柴可夫金祖汉许丽丽
Owner 浙江省中药研究所有限公司
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