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Use of resveratrol or naringenin in preventing and treating diabetic nephropathy

A technology for diabetic nephropathy and resveratrol, applied in the direction of urinary system diseases, medical preparations containing active ingredients, effective ingredients of hydroxyl compounds, etc.

Active Publication Date: 2009-04-29
ZHAOMING ZEKANG (BEIJING) BIO-PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been found in the prior art that resveratrol and naringenin can reduce the level of TGF-β1 in the serum and kidney tissue of diabetic mice and reduce the kidney damage of diabetic mice

Method used

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  • Use of resveratrol or naringenin in preventing and treating diabetic nephropathy
  • Use of resveratrol or naringenin in preventing and treating diabetic nephropathy
  • Use of resveratrol or naringenin in preventing and treating diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: Naringenin tablet

[0043] Take 100mg / kg of naringenin, add conventional excipients, and make tablets according to conventional processes for the prevention and treatment of diabetic nephropathy, with a daily dosage of 300-1000mg / day.

Embodiment 2

[0044] Embodiment 2: resveratrol capsules

[0045] Take resveratrol 50mg / kg, add conventional auxiliary materials, and make capsules according to conventional processes, for preventing and treating diabetic nephropathy, and the daily dosage is 300-1000mg / day.

Embodiment 3

[0046] Embodiment 3: Naringenin injection

[0047] Take 100 mg / kg of naringenin, add conventional auxiliary materials, and make injections according to conventional processes, for the prevention and treatment of diabetic nephropathy, and the daily dosage is 5-15 mg / day.

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PUM

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Abstract

The invention discloses the application of resveratrol and naringenin, particularly the application of the resveratrol and the naringenin in restraining the level increasing of the transforming growth factor Beta 1 in the human body and preparing medicines used for preventing or treating diabetes and nephropathy.

Description

technical field [0001] The present invention relates to the application of resveratrol or naringenin, in particular to resveratrol or naringenin in the prevention and treatment of diabetes by reducing the level of transforming growth factor-β1 (transforming growth factor betal, TGF-β1) in the body application in renal disease. Background technique [0002] The incidence of diabetes will increase globally in the next 10 years. Among them, life-threatening diabetic nephropathy is the leading cause of diabetes death in Western countries, and it is also becoming the main cause of diabetes death in Asia and developing countries in the future. At present, measures to reduce the risk of diabetic nephropathy mainly include strict control of blood sugar, high blood pressure and restriction of dietary protein intake, which can reduce the risk of death caused by renal failure by 20%. [0003] Diabetic nephropathy manifests as changes in glomerular function and structure, including inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/05A61P31/10A61P13/12
Inventor 任武贤杜钢军禹玉洪张洪雁
Owner ZHAOMING ZEKANG (BEIJING) BIO-PHARM TECH CO LTD
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