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Collagen spherical honeycombed grain material, producing method and apparatus thereof

A technology of porous particles and spherical particles, applied in dental preparations, pharmaceutical formulations, dental prostheses, etc., can solve the problems of high packing density, large distribution range of microsphere diameters, unfavorable new tissue growth, etc. Good particle size uniformity

Inactive Publication Date: 2009-04-08
JIANGSU HAIJIAN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microspheres prepared by these methods have a large diameter distribution range and a high packing density. When applied to tissue filling, the pores between the particles are too small, which is not conducive to the growth of new tissues.

Method used

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  • Collagen spherical honeycombed grain material, producing method and apparatus thereof
  • Collagen spherical honeycombed grain material, producing method and apparatus thereof
  • Collagen spherical honeycombed grain material, producing method and apparatus thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Prepare the collagen acetic acid solution whose mass concentration is 1.5% of the acetic acid solution whose collagen quality accounts for 3% of the whole solution quality, fully stir to make the collagen dissolve completely;

[0028] (2) if figure 1 As shown, the prepared collagen acetic acid solution is added to the storage tank 4 from the feeding port 1, and the pressure in the storage tank 4 is controlled by the pressure gauge 2 and the pressure control valve 3 to be 0.08MPa to ensure that the collagen solution is guided from φ0.5mm The tube 6 flows out evenly, and is controlled by the flow control valve 5 to flow out evenly at a speed of 10 drops / min. The collagen solution flowing out from the catheter 6 grows to a nearly spherical particle of φ0.8mm at the mouth of the tube and then drips. During the falling process, it forms a spherical shape due to the effect of surface tension, and then drips into the condensate in the heat preservation container 8. Conden...

Embodiment 2

[0031] (1) Prepare the collagen acetic acid solution whose mass concentration is 5% of the acetic acid solution whose collagen quality accounts for 15% of the whole solution quality, stirring and fully dissolving;

[0032] (2) The prepared collagen acetic acid solution is added to the storage tank 4 from the feeding port 1, and the pressure in the storage tank 4 is controlled by the pressure gauge 2 and the pressure control valve 3 to be 0.5MPa, so as to ensure that the collagen solution flows from the φ 3mm catheter tube 6 Flows evenly. The collagen solution flowing out from the catheter 6 grows to a nearly spherical particle of φ4mm at the mouth of the tube and then drips. During the falling process, it forms a spherical shape due to the effect of surface tension, and then drips into the condensate 7 in the heat preservation container 8. Condensation, the temperature of the condensate is -20°C, and spherical particles are formed.

[0033] (3) The condensed microspheres were...

Embodiment 3

[0035] (1) prepare the collagen acetic acid solution whose mass concentration is 3% of the acetic acid solution whose collagen quality accounts for 8% of the whole solution quality, stirring and fully dissolving;

[0036] (2) The prepared collagen solution is added to the storage tank 4 from the feeding port 1, and the pressure in the storage tank 4 is controlled by the pressure gauge 2 and the pressure control valve 3 to be 2.15MPa to ensure that the collagen solution is fed from the φ 1.8mm catheter 6 out evenly. The collagen solution flowing out from the catheter 6 grows to a nearly spherical particle of φ2.6 mm at the mouth of the tube and then drips. During the falling process, it forms a spherical shape due to the effect of surface tension, and then drips into the condensate in the heat preservation container 8. Condensate in 7, the temperature of the condensate is -15°C, the condensate is vegetable oil, and forms spherical particles.

[0037] (3) The condensed microsph...

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Abstract

The invention relates to a collagen spherical porous granular material, a method and a device for preparing the same. The preparation method comprises the following steps: step one, collagen acetum solution is prepared by 1-5 mass percent acetum, wherein the mass of the collagen accounts for 3 to 15 percent of the total mass of the collagen acetum solution; step two, the solution is added to a storage tank from a charging hole, and uniformly flows out at a speed of 10-60 drops / minute under the condition that the pressure is controlled to between 0.08 and 0.5MPa, and the collagen acetum solution flowing out from a catheter is dripped into a condensed fluid for condensation so as to form the collagen spherical porous granular material with good sphericity and homogeneous grain diameter; and step three, the spherical grains are separated, undergo freeze drying and then cross-linking treatment for 3 to 24 hours, and then are washed by absolute ethyl alcohol, so as to obtain the collagen spherical porous granular material. The spherical granular material has the homogeneous particle size distribution, contains a large number of mutually communicated micropores, has high specific surface, and can be applied to tissue restoration and drug release.

Description

technical field [0001] The invention belongs to a preparation technology of a spherical granular material applied in the field of biomedicine, and in particular relates to a preparation method of a natural polymer collagen spherical porous granular material. Background technique [0002] current technology: [0003] Collagen or collagen is a biological polymer synthesized by animal cells. It is widely found in animal bones, tendons, cartilage, skin and other connective tissues. It accounts for about 30% of the total protein of mammals and is an important protein in the human body. Components of the extracellular matrix. Collagen has good biological properties and can be used as a support for tissues. It has a major impact on the normal function of cells, tissues and even organs and the repair of trauma. A large number of research results show that the performance of collagen can be used as a culture substrate for epidermal cells, fibroblasts, corneal cells, chondrocytes an...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/56A61K6/08A61K6/884
Inventor 董寅生林萍华郭超盛晓波储成林浦跃朴
Owner JIANGSU HAIJIAN
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