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Uses of sugar apple lactone monomeric compound in preparing medicament for treating lung cancer, mammary cancer or liver cancer

A technology of annona lactones and compounds, which is applied in the field of preparation of drugs for treating lung cancer, breast cancer or liver cancer, can solve the problems of unsatisfactory curative effect, large toxic and side effects, and low cancer curative effect, and achieve the goal of improving the clinical curative effect of anticancer Effect

Inactive Publication Date: 2009-04-08
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapeutic drugs have a certain effect on cancer, but they have severe side effects

Method used

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  • Uses of sugar apple lactone monomeric compound in preparing medicament for treating lung cancer, mammary cancer or liver cancer
  • Uses of sugar apple lactone monomeric compound in preparing medicament for treating lung cancer, mammary cancer or liver cancer
  • Uses of sugar apple lactone monomeric compound in preparing medicament for treating lung cancer, mammary cancer or liver cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Inhibitory effect of anemone lactone monomer compound bullatacin on transplanted lung cancer in mice

[0017] 1. Experimental animals and tumor strains

[0018] Male healthy C57BL / 6 mice, weighing 18-22 g, aged 6-8 weeks, were purchased from the Animal Experiment Center of our school; mouse Lewis lung cancer tumor strains were purchased from the Animal Experiment Center of Jiangsu Cancer Institute.

[0019] 2. Modeling and experimental methods

[0020] There were 60 C57BL / 6 mice, 10 were randomly reserved in proportion as the negative control group, and the remaining 50 were used for modeling. Prepare Lewis lung cancer tumor-bearing mice, peel off the tumor tissue in the vigorous growth period, and select a well-growing tumor of 1.5mm 3 Left and right, according to tumor (g): normal saline (ml) ratio of 1:3 homogenate, adjust the number of cells to 2 × 10 6 / ml. Select healthy mice, and inoculate 0.2 ml subcutaneously in the right axilla of each mouse und...

Embodiment 2

[0027] Example 2: Inhibitory effect of anemone lactone monomer compound bullatacin on transplanted breast cancer

[0028] 1. Experimental animals and tumor strains

[0029] Female healthy TA2 mice, weighing 18-22 g, aged 6-8 weeks, were purchased from the Animal Experiment Center of our school; the mouse breast cancer cell line MA-891 was purchased from the Animal Experiment Center of Jiangsu Cancer Institute.

[0030] 2. Modeling and experimental methods

[0031] There were 60 TA2 mice, 10 were randomly reserved in proportion as the negative control group, and the remaining 50 were used for modeling. Take MA-891 mouse breast cancer cells in logarithmic growth phase cultured in vitro, and adjust the cell concentration to 1×10 7 / ml. Under sterile conditions, MA-891 mouse breast cancer cells were inoculated subcutaneously in the right axilla of TA2 mice, the inoculation volume was 0.2ml / mouse (the number of cells was 2×10 6 / Only). The entire inoculation process must be ca...

Embodiment 3

[0038] Example 3: Inhibitory effect of anemone lactone monomer compound bullatacin on transplanted liver cancer

[0039] 1. Experimental animals and tumor strains

[0040] Male healthy Kunming mice, weighing 18-22g, aged 6-8 weeks, were from the Animal Experiment Center of our school; the HepS tumor strain of Kunming mice with ascites type rat liver cancer was purchased from the Animal Experiment Center of Jiangsu Cancer Institute. The mice were reared in the animal experiment room of the Animal Experiment Center of Nanjing University of Traditional Chinese Medicine, with a temperature of 21-25°C and a humidity of 45%-55%.

[0041] 2. Modeling and experimental methods

[0042] Of the 60 male mice of the Kunming species, 10 were randomly reserved in proportion as the negative control group, and the remaining 50 were used for modeling. Aseptically extract the ascites of mice inoculated with HepS tumors for 8 days, dilute 10 times with normal saline, stain with 0.02% eosin, drop ...

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PUM

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Abstract

The invention discloses novel application of an annonaceous acetogenin compound monomer bullatacin, in particular application of the annonaceous acetogenin compound monomer in the preparation of medicaments for treating lung cancer, mammary cancer or liver cancer. The experimental results of pharmacological tests of anticarcinogen in animals show that the annonaceous acetogenin monomer bullatacin can obviously inhibit the growth of the lung cancer, the mammary cancer, and the liver cancer, and the anti-tumor activity in vivo is hundreds of times higher than that of the prior clinical first-line chemotherapy drug 5-fluorouracil, thus the annonaceous acetogenin compound monomer bullatacin can be used in the preparation of the medicaments for treating the lung cancer, the mammary cancer, or the liver cancer.

Description

1. Technical field [0001] The invention relates to a new application of bullatacin, an anemone lactone monomer compound, in particular to the application of the compound in the preparation of medicines for treating lung cancer, breast cancer or liver cancer. 2. Background technology [0002] Cancer is a formidable enemy that endangers human health. There are about 1.6 million new cancer cases in my country every year, and about 1.3 million people die from cancer every year. The number of deaths due to cancer in the country is increasing year by year. my country is a high-incidence area for lung cancer, breast cancer, liver cancer and other cancers. Cancer mortality stay high. [0003] There are currently no effective drugs that cure most cancer patients. Although chemotherapeutic drugs have certain curative effects on cancer, they have severe side effects, and Chinese patent medicines generally have low curative effects on cancer, and the curative effects are not ideal. ...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P35/00
Inventor 章永红
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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