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Bitongning gel and its preparing method

A technology of gel and nasal passage, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Absorption etc.

Inactive Publication Date: 2009-04-01
童玉新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bitongning currently only sells drops in the market. Due to the short contact time between the drops and the nasal mucosa, the absorption of the drug is affected, thereby affecting its clinical efficacy.

Method used

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  • Bitongning gel and its preparing method
  • Bitongning gel and its preparing method
  • Bitongning gel and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Nasal Tonic Gel:

[0073] (1), the parts by weight of each raw drug described are

[0074] Goose does not eat grass 500g

[0075] Magnolias 125g

[0076] (2), the parts by weight of each component in the gel are

[0077] 500g goose does not eat grass and 125g magnolia steam distilled aromatic water 8-10g carbomer 24g propylene glycol 480g polysorbate 80 120g ethylparaben 12g disodium edetate 1.2g

[0078] (3), the pH value of triethanolamine-adjusting nasal tonic gel is 6-7.

[0079] The preparation method according to the above prescription is:

[0080] 1. Take 500g goose that does not eat grass, 125g magnolia, heat and distill, adjust the drop rate of aromatic water to about 5ml / min (according to 3.5 hours to collect 1000ml budget), and collect 8-10g aromatic water in sections;

[0081] 2. Take disodium edetate and add some aromatic water to dissolve it, then add carbomer, let it stand for 24 hours, stir well, and get carbomer gel;

[0082] 3. Take propylene gly...

Embodiment 2

[0084] Nasal Tonic Gel:

[0085] (1), the parts by weight of each raw drug described are:

[0086] Goose does not eat grass 250g

[0087] Magnolias 65g

[0088] (2), the parts by weight of each component in the gel are

[0089] 250g goose does not eat grass and 65g magnolia steam distillation of aromatic water 4-5g carbomer 32g propylene glycol 360g polysorbate 80 180g ethylparaben 6g disodium edetate 0.8g

[0090] (3), the pH value of triethanolamine-adjusting nasal tonic gel is 6-7.

[0091] The preparation method according to the above formula is:

[0092] 1. Take 250g goose that does not eat grass, 65g magnolia, heat and distill, adjust the drop rate of aromatic water to about 5ml / min (according to the budget of 1000ml collected in 3.5 hours), and collect 4-5g aromatic water in sections;

[0093] 2. Take disodium edetate and add appropriate amount of aromatic water to dissolve it, then add carbomer, let it stand for 24 hours, stir well, and get carbomer gel;

[0094]...

Embodiment 3

[0096] Nasal Tonic Gel:

[0097] (1), the parts by weight of each raw drug described are

[0098] Goose does not eat grass 750g

[0099] Magnolias 180g

[0100] (2), the parts by weight of each component in the gel are

[0101] 750g goose does not eat grass and 180g magnolia steam distillation to obtain aromatic water 14-15g carbomer 16g propylene glycol 600g polysorbate 80 60g ethylparaben 18g disodium edetate 1.6g

[0102] (3), the pH value of triethanolamine-adjusting nasal tonic gel is 6-7.

[0103] The preparation method according to the above formula is:

[0104] 1. Take 750g goose that does not eat grass, 180g magnolia, heat and distill, adjust the drop rate of aromatic water to about 5ml / min (according to 3.5 hours to collect 1000ml budget), and collect 14-15g aromatic water in sections;

[0105] 2. Take disodium edetate and add appropriate amount of aromatic water to dissolve it, then add carbomer, let it stand for 24 hours, stir well, and get carbomer gel;

[0...

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Abstract

The invention discloses a Bitongning gel and a preparation method thereof, the drug ingredients are small centipeda herb and biond magnolia flower wet distillation aromatic water, the gel matrix is carbomer, the solvent is propylene glycol and polysorbate 80, the antibacterial agent is ethyl hydroxybenzoate, the stabilizer is ethylenediaminetetraacetic acid disodium salt and the pH regulator is triethanolamine. The Bitongning gel has transparent gel, good dispersion and storage resistance, can prolong the contact time of drug with nasal mucosa and be conductive to improving the bioavailability and the efficacy.

Description

technical field [0001] The invention relates to a gel preparation, specifically a Bitongning gel and a preparation method thereof. Background technique [0002] Chronic sinusitis, cold nasal congestion is a common disease, frequently-occurring disease. Bitongning currently only has drops on the market. Because the contact time between the drops and the nasal mucosa is short, the absorption of the medicine is affected, thereby affecting its clinical efficacy. Contents of the invention [0003] The object of the present invention is to provide a Bitongning gel and a preparation method thereof, which can prolong the contact time between the medicine and the nasal mucous membrane, and help improve the bioavailability and curative effect. [0004] Technical scheme of the present invention is as follows: [0005] Natongning gel is characterized in that: [0006] (1), the parts by weight of each raw material Chinese medicine are: [0007] Goose does not eat grass 250—750 [...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61K9/00A61K47/34A61P11/02A61K47/26
Inventor 童玉新
Owner 童玉新
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