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Use of snow ganoderma lucidum total saponin in preparing antiviral property hepatitis medicine

A technology for viral hepatitis and total saponins, applied in antiviral agents, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as the treatment of viral hepatitis with total saponins from snow ganoderma lucidum.

Inactive Publication Date: 2009-03-18
周以智
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report that the total saponins of Ganoderma lucidum is used for the treatment of viral hepatitis

Method used

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  • Use of snow ganoderma lucidum total saponin in preparing antiviral property hepatitis medicine
  • Use of snow ganoderma lucidum total saponin in preparing antiviral property hepatitis medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0013] Inhibition test of the total saponins of Snow Ganoderma lucidum on the secretion of two antigens, HbsAg and HbeAg:

[0014] HepG 2.2.15 in logarithmic growth phase by 10 4 / ml inoculated in a 96-well cell culture plate, 180 μl per hole; after the cells adhered to the wall (24h), the drug was added, and the experiment was divided into 5 groups. ② Negative control group (blank control group): 10% FBS RPMI 1640 medium; ③ Positive control group: lamivudine (10 -6 mol / L); ④ vehicle control group: 1% DMSO. Set up 3 replicate wells for each concentration, 20 μl per well (1% DMSO in the final concentration of each drug), 37°C, 5% CO 2 The expressions of HBsAg and HBeAg in the culture supernatant were measured after incubation for 72 hours and 96 hours respectively.

[0015] The test showed that the total saponins of Snow Ganoderma lucidum inhibited the secretion of both HBsAg and HBeAg antigens, and reached the peak at 96 hours of the experiment, and the therapeutic index wa...

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PUM

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Abstract

The invention relates to a new use of Arenaria brevipetala total saponin, in particular to the application in preparation of anti-virus hepatitis medicine. Arenaria brevipetala total saponin is prepared into dosage forms, such as tablets, capsules, oral liquid, medicinal granules, injection, and the like, for treating virus hepatitis. Taking Arenaria brevipetala total saponin may improve the immunological competence of patients, has obvious inhibitory action for exudation of the two antigens HbsAg and HbeAg, with the therapeutic index reaching 3.17 and 6.28 respectively. Further, the Arenaria brevipetala total saponin can overcome common toxic side effect and rebound phenomenon of western medicine treating virus hepatitis, and is a new drug with safety, determined curative effect, no rebound and broad adaptation for treating virus hepatitis.

Description

technical field [0001] The invention relates to the use of total saponins of snow ganoderma lucidum, in particular to the application of total saponins of snow ganoderma lucidum in the preparation of antiviral hepatitis drugs. Background technique [0002] Chronic hepatitis B virus infection is one of the most serious infectious diseases in humans. Statistics show that more than 400 million people around the world suffer from chronic HBV infection, and about 1 million people die from it every year. In my country, the number of chronic hepatitis B virus carriers has reached about 120 million, and there are 30 million chronic hepatitis B patients. What's more serious is that infected individuals may also develop liver cirrhosis and liver cancer, which is extremely harmful. At present, the treatment effect of HBV infection is still not satisfactory, only 20% of patients benefit from the use of recombinant interferon and nucleoside analogues such as lamivudine. Therefore, it ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/36A61P1/16A61P31/20
Inventor 周以智徐庆龚受基冯梅
Owner 周以智
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