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Use of heaven tree extract in preparing antineoplastic medicine

The technology of anti-tumor drugs and extracts is applied in the application field of Ailanthus altissima extracts in the preparation of anti-tumor drugs, and can solve problems such as no reports on the application, and achieve the effects of low cost and simple method.

Inactive Publication Date: 2009-03-18
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report on the application of Ailanthus sinensis in the preparation of antineoplastic drugs

Method used

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  • Use of heaven tree extract in preparing antineoplastic medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, the preparation of Ailanthus sinensis extract

[0018] Get Ailanthus bark (Ningbo Dekang Biological Products Co., Ltd.) 200g, mix it with 95% ethanol (ethanol: water=95: 5, volume ratio) with the mass fraction ratio of 1: 3 (Ailanthus bark: 95% ethanol) , reflux extraction at 60°C for 3h, suction filtration, and collect the first reflux extract 1 and filter residue 1; mix all the filter residue 1 obtained with 95% ethanol, the amount of 95% ethanol is the same as the first time, at 60 Extract under the condition of ℃ for 3 hours, collect the second reflux extract 2 and filter residue 2, and combine the extract 2 and extract 1; mix all the filter residue 2 obtained with 95% ethanol, the amount of 95% ethanol is the same as that of the first Same, reflux extraction at 60°C for 3 hours, suction filtration, and collect the third reflux extract 3; combine extract 1, extract 2 and extract 3, concentrate the obtained extract under reduced pressure, and vacuum dry...

Embodiment 2

[0019] Embodiment 2, the application of Ailanthus sinensis extract in inhibiting the growth of tumor cells

[0020] The logarithmically grown tumor cells (human liver cancer cell BEL-7402, human colon cancer cell HCT-8, human lung cancer cell A-549) were digested with 0.25% trypsin, and then treated with 10% (volume percentage) fetal Suspend the cells in DMEM complete medium of bovine serum to make a cell suspension, and dilute each tumor cell to 1.0×10 5 cells / mL, and then inoculated into 96-well culture plate, 200uL per well, each tumor cell was inoculated into 3 wells respectively, at 37°C, 5% CO 2 Cultivate in an incubator for 24 hours; then pour out the culture solution in each well.

[0021] The Ailanthus extract prepared in Example 1 was dissolved in DMSO, and then diluted with DMEM complete medium to obtain a solution of the Ailanthus extract, the final concentration of the Ailanthus extract was 50ug / mL, and the concentration of DMSO was 10% (volume percentage).

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Abstract

The invention discloses a new use of heaven tree extract. The new use lies in that the heaven tree extract is used for preparing antineoplastic drugs; the heaven tree extract is prepared according to the following method: heaven tree skin is used as raw material which is then extracted by water and / or an organic solvent to obtain the extract. The heaven tree extract provided by the invention is of significance in preparing antineoplastic drugs, especially drugs for resisting liver cancer, lung cancer and colon cancer.

Description

technical field [0001] The invention relates to the application of Ailanthus ailanthus extract in the preparation of antitumor drugs. Background technique [0002] Liver cancer is one of the common malignant tumors in our country, and it is the second cancer "killer" in our country, which is common in middle-aged men. Because of its high degree of malignancy and rapid disease progression, patients generally have no discomfort in the early stage, but once symptoms appear and go to the doctor, it is already in the middle and late stages. Therefore, the treatment of liver cancer is very difficult, and the average patient's survival time after onset is only 6 months, which is called "the king of cancer". According to the survey results, the top three new cancers in men are lung cancer, colon cancer, and nasopharyngeal cancer, and breast cancer, colon cancer, and lung cancer in women, which fully demonstrates the harm of lung cancer and colon cancer in the new cancer group sex....

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P35/00
Inventor 唐亚林谭莉戴玮刘岩
Owner INST OF CHEM CHINESE ACAD OF SCI
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