Mouth spray for preventing and treating nausea and emesis after tumor chemotherapy and radiotheraphy and preparation method thereof
A technology of oral spray, chemotherapy and radiotherapy, applied in the field of pharmaceutical preparations, to achieve the effects of dose control, simple operation, and easy dose
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Embodiment 1
[0031] Dissolve 500-1000g of palonosetron hydrochloride in 8000-9000g of sodium citrate buffer solution, and mix 250-500g of water-soluble azone, 250-500g of propylene glycol under constant stirring (200±100 rpm). , 0.2-2g sodium saccharin and 10-20g lysostaphin are added slowly, and stirring is continued for 10-60 minutes after the addition is completed.
Embodiment 2
[0033] Dissolve 500-1000g of granisetron in 8000-9000g of sodium citrate buffer, under constant stirring (200±100 rpm), add 250-500g of water-soluble azone, 250-500g of propylene glycol, 0.2- Add 2g of sodium saccharin and 10-20g of lysostaphin slowly, and continue stirring for 10-60 minutes after the addition is complete.
Embodiment 3
[0035] Dissolve 500-1000g of ondansetron in 8000-9000g of sodium citrate buffer solution, and mix 250-500g of water-soluble azone, 250-500g of propylene glycol, 0.2 Slowly add ~2g sodium saccharin and 10~20g lysostaphin, and continue stirring for 10~60 minutes after adding.
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