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Use of elderberry extract

A technology of elderberry and extract, applied in the field of virus treatment, can solve the problem of not being able to provide enough effective vaccines or antidote, etc.

Inactive Publication Date: 2009-03-11
HEALTHCARE BRANDS INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As mentioned above, the H5N1 strain of influenza A virus is a relatively new strain of influenza virus that is feared to trigger the next influenza pandemic, for which there are currently not enough effective vaccines or antidote available

Method used

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  • Use of elderberry extract
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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0043] The preparation of pharmaceutical compositions and formulations is well known in the art and described in various documents and textbooks, see for example Remington's Pharmaceutical Sciences, Gennaro A.R.ed, Mack publishing Co., Eaton, PA, 1990 especially 1521- 1712 pages.

[0044] The present invention is defined by the claims, and the content of the claims is included in the scope of disclosure of the specification.

[0045] It is to be understood that this invention is not limited to the particular embodiments disclosed and described, and that the process steps and materials disclosed herein may vary slightly. It should also be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting, so that the scope of the invention is limited only by the appended claims and their equivalents.

[0046] It should be noted that, as used in this specification and the appended claims, the singular for...

Embodiment 1

[0073] Example 1: Cytotoxicity

[0074] Crystal Violet Test

[0075]A crystal violet test was performed to calculate the The survival rate of MDCK cells after culture. The result is as figure 1 shown. Press 1:80 or higher The diluent completely eliminates Any toxic effects on MDCK cells.

[0076] cell observation

[0077] The viability threshold for toxicity was determined to be 90% in this assay.

Embodiment 2

[0078] Embodiment 2: Virus titer reduction test

[0079] 40 μl virus (reaction total titer is 4.0-log 10 TCID 50 / ml) was added to 360 μl of experimental samples and incubated at room temperature for 0.5, 5, 10, 30 and 60 minutes. The reaction mixture was added to the target cells, and after a 10-fold serial dilution, it was dropped into a 96-well plate. Plates were then incubated for 60 minutes. After removal of surface suspensions and washing the plate twice with PBS, 100 [mu]l of standard infection medium was added to each well. Cells were cultured for 3 days at the measured virus titer point.

[0080] The antiviral positive control consisted of a 5-minute pretreatment of the virus with a citrate buffer solution at pH 3.5 (a known citrate buffer incubation time point that showed antiviral activity against influenza A virus—no public data).

[0081] therapeutic index

[0082] Therapeutic index is an indicator of the specificity of a substance's toxicity to a virus ...

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Abstract

The present invention relates to the field of viral therapy. More specifically, the present invention relates to the use of elderberry extract in the preparation of a pharmaceutical formulation for the treatment of an influenza viral infection. It also relates to a novel method of treatment of the avian flu virus, through the administration of elderberry extract.

Description

technical field [0001] The present invention relates to the field of viral therapy. More specifically, the present invention relates to the use of elderberry extracts in the preparation of pharmaceutical preparations for the treatment of influenza virus infections. The present invention also relates to a method of treating avian influenza virus by administering an elderberry extract. [0002] All publications mentioned in this application, including all references cited herein, are hereby incorporated by reference in their entirety. Background technique [0003] The spread of avian influenza from the Far East to Eastern European countries has raised concerns about a possible influenza pandemic and highlighted the need to explore a preventive and / or therapeutic approach. [0004] Influenza viruses belong to the RNA virus family, Orthomyxoviridae (myxo=mucus). Orthomyxoviridae, and the closely related Paramyxoviridae family of RNA viruses, all have negative-strand single-st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/35A61P31/16
CPCA61K36/35A61P31/12A61P31/16
Inventor M·穆姆久奥卢
Owner HEALTHCARE BRANDS INT
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