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Pharmaceutical composition for easing pruritus

A composition and drug technology, applied in the field of pharmaceutical compositions for inhibiting and/or alleviating pruritus, can solve problems such as side effects and unsuitable patients with chronic pruritus

Inactive Publication Date: 2010-12-08
SUNNY PHARMTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many patients demonstrate persistent pruritus despite treatment with antihistamines, 5-HT receptor antagonists, and / or immunosuppressants, because these agents are only suitable for short-term treatment and have side effects, and Not suitable for patients with chronic itching

Method used

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  • Pharmaceutical composition for easing pruritus
  • Pharmaceutical composition for easing pruritus
  • Pharmaceutical composition for easing pruritus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] 1. Preparation of various types of oily ointments, creams and gels

[0025] A. Preparation of phenylbutyrate oily ointment

[0026] Mix 65 grams of white petrolatum (Riedel-de Haen), 15 grams of cetyl alcohol (Riedel-de Haen), 260 grams of soft paraffin (Merck), 155 grams of liquid paraffin (Merck), and 5 grams of 4-phenylbutyrate (Merck) were mixed in a beaker and heated to 70°C to form a paste. The paste was stirred at 400 rpm for 1 hour and cooled to room temperature.

[0027] B. Preparation of Phenylbutyrate Emulsion

[0028] First ingredient: 70 grams of Tefose 63 , 20 grams of Superpolystate , 10 grams of Coster 5000 , 15 grams of Myriyol 318 , 15 grams of Coster 5088 , and 15 grams of GMS SE (both available from local suppliers) were mixed in a beaker and heated to 70°C.

[0029] Second component: 5.739 grams of sodium 4-phenylbutyrate (Triple Crown America, Inc.), 0.125 grams of methylparaben (Merck), 0.075 grams of propylparaben (Merck) , and 14...

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PUM

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Abstract

The invention relates to a pharmaceutical composite which inhibits and / or relieves pruritus caused by dermatosis, mucosa disease or systemic disease or lesion, and is made from derivatives, salt or solvate of phenyl butyric acid and short chain fatty acid with effective dose and a carrier which is acceptable pharmaceutically.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for inhibiting and / or alleviating pruritus, and in particular to a pharmaceutical composition for inhibiting and / or alleviating pruritus by using phenylbutyric acid derivatives or short-chain fatty acid derivatives. Background technique [0002] Pruritus produces symptoms such as discomfort and itching, sometimes causing redness, swelling and pain on the patient's skin. Pruritus is considered to be a broad range of physical, chemical and / or biological stimuli that can be internal or external. Pruritus is assigned to a specific skin condition, eg, drug allergy, insect bites, environmental allergens, or systemic disease, eg, thyrotoxicosis, diabetes, uremia, iron deficiency anemia, delusional parasitosis , Polycythemia vera, cholestasis, Hodgkin's disease. Although pruritus is more common in the skin, it can also occur in non-cutaneous sites such as mucous membranes. Therefore, the cause of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61K31/19A61K31/16A61K31/216A61K31/44A61K45/06A61K9/00A61K9/06A61K9/107A61K9/127A61P17/04A61P17/00
Inventor 钟邑林贝南谋张葳葳
Owner SUNNY PHARMTECH
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