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Cistanche oligosaccharide, preparation and application thereof

A technology of Cistanche deserticola and total oligosaccharides, which is applied in the preparation of sugar derivatives, chemical instruments and methods, oligosaccharides, etc., can solve the problems of intestinal wall cell function and morphological changes, large intestinal epithelial damage, and complex extraction processes, and achieve enhanced The effect of intestinal peristalsis, promotion of fecal excretion, and elimination of purification process

Active Publication Date: 2009-01-28
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the survey, now about 60%-70% of constipation patients in China often self-administer stimulant laxatives such as Guodao (the main component is phenolphthalein) and external medicines such as Kaisailu, but most of these constipation medicines are stimulant laxatives. Taking or abuse may cause serious potential disorders in the body, such as hypokalemia, chronic hyponatremia, and progressive renal insufficiency, etc., and may also cause changes in the function and shape of intestinal wall cells, thereby causing damage to the large intestinal epithelium. It may cause abdominal distension, increased gas, and may also cause a vicious cycle of dependence on such laxatives
It is reported in the literature that the galactitol component in Cistanche deserticola has the effect of laxative, but there are defects such as complicated extraction process

Method used

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  • Cistanche oligosaccharide, preparation and application thereof
  • Cistanche oligosaccharide, preparation and application thereof
  • Cistanche oligosaccharide, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Take 100g of Herba Cistanche, cut into slices, add crude drug 1L of water, heat and reflux to extract for 1 hour, filter, and the filtrate is used for later use; Concentrate under pressure until the relative density is 1.20 at 50°C to obtain concentrated solution I; place the concentrated solution I at room temperature, slowly add 80% ethanol to make the alcohol content reach 70%, place it in a 6°C freezer for 24 hours, filter, and the filtrate reduces Concentrate under pressure to obtain Concentrate II; place Concentrate II at room temperature, slowly add to AB-8 macroporous adsorption resin column with resin column diameter-to-height ratio of 1:12, the ratio of medicinal material to dry resin is 1:1, and use 2 Times column volume of deionized water was eluted, and the water eluate was concentrated under reduced pressure to a thick paste to obtain 28.6 g of total oligosaccharides of Cistanche deserticola; 6 h 12 o 6 Not less than 58%, the total oligosaccharides conta...

Embodiment 2

[0070] Take 100g of Herba Cistanche, cut into slices, add crude drug 0.6L of water, heat and reflux for extraction for 3 hours, filter to obtain the filtrate, and set aside; add 0.4L of water to the dregs, extract 3 times, each time for 0.5 hours, filter, and combine four The second filtrate was concentrated under reduced pressure until the relative density was 1.10 at 70°C to obtain the concentrated solution I. Place the concentrated solution I at room temperature, slowly add 95% ethanol to make the alcohol content reach 50%, place it in a refrigerator at 2°C for 6 hours, filter When the filtrate was concentrated under reduced pressure to no alcohol, the relative density was 1.10, and the concentrated solution II was obtained. The concentrated solution II was placed at room temperature, and slowly added to the HPD-100 macroporous adsorption resin column with a resin column diameter-to-height ratio of 1:6. , the ratio of medicinal material to dry resin is 1:3, elute with 2 time...

Embodiment 3

[0072] Take 100g of Herba Cistanche, cut into slices, add crude drug 0.8L of water to extract under reflux for 2 hours, filter, and use the filtrate for later use; extract the dregs with 0.6L of water for 2 times, each time for 1 hour, and filter; combine the filtrate three times, Concentrate under reduced pressure to a relative density of 1.15 at 60°C to obtain concentrated solution I, place it at room temperature, slowly add 90% ethanol to make the alcohol content reach 60%, place it in a refrigerator at 4°C for 12 hours, filter, and concentrate the filtrate under reduced pressure. The concentrated solution II was obtained, placed at room temperature, and slowly added to a ME-2 macroporous adsorption resin column with a resin column diameter-to-height ratio of 1:9. The ratio of medicinal materials to dry resin was 1:2, and deionized water with 1.5 column volume Elution, collect the water eluate, concentrate under reduced pressure to a thick paste, and obtain 39.5 g of total o...

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Abstract

The invention discloses total oligose in cistanche deserticola and a preparation method and application thereof. In the total oligose in cistanche deserticola of the invention, the content of the contained total oligose is not less than 40 to 60 percent based on glucose (C6H12O6), and the content of galactitol (C6H1>O6) contained in the total oligose ranges from 0.0 to 25.0 percent. Used as drugs for relaxing bowel, the total oligose in cistanche deserticola of the invention eliminates the complex purification process required by purifying the galactitol from the cistanche deserticola, leads to maximum utilization of drug resources of cistanche deserticola and enhances the drug effect, thus having the advantages of definite healing efficacy, few side-effects and large group of application people. Due to moderate bowel-relaxing effect, the total oligose in cistanche deserticola is especially suitable for the old, lying-in women or valetudinarians.

Description

technical field [0001] The invention relates to an extract of Cistanche deserticola and its preparation method and use, in particular to total oligosaccharides of Cistanche deserticola and its preparation method and use. Background technique [0002] Constipation has gradually become one of the common diseases of urban residents in recent years, and the incidence rate is on the rise. According to the survey, now about 60%-70% of constipation patients in China often self-administer stimulant laxatives such as Guodao (the main component is phenolphthalein) and external medicines such as Kaisailu, but most of these constipation medicines are stimulant laxatives. Taking or abuse may cause serious potential disorders in the body, such as hypokalemia, chronic hyponatremia, and progressive renal insufficiency, etc., and may also cause changes in the function and shape of intestinal wall cells, thereby causing damage to the large intestinal epithelium. It may cause abdominal disten...

Claims

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Application Information

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IPC IPC(8): C07H3/06C07H1/08A61K36/64
Inventor 屠鹏飞张国恩戴昉
Owner JIANGSU KANION PHARMA CO LTD
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