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Synthesis of quercetin platinum

A technology for quercetin and a synthesis method, which are applied in the directions of drug combinations, organic active ingredients, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2009-01-28
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Reaction of quercetin and platinum compound to synthesize quercetin platinum has not been reported at home and abroad

Method used

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  • Synthesis of quercetin platinum
  • Synthesis of quercetin platinum

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Experimental program
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Embodiment Construction

[0015] Synthesis of quercetin platinum complex

[0016] Take 0.302g (1mmol) of quercetin, add 20ml of methanol, and stir to dissolve. Take another 0.337g (1mmol) of platinum tetrachloride, add 20ml of methanol, and stir to completely dissolve it. Mix the two, adjust the pH to 8.4 with ammonia, heat, back distill for 4h, and filter. The precipitate was dissolved in methanol, applied to a polyamide chromatography column, eluted with a gradient of methanol solutions of different concentrations, collected the eluent in the set interval, and evaporated the solvent by a rotary evaporator. The obtained solid was re-extracted with ethyl acetate several times to obtain a dark brown yellow solid.

[0017] The inhibitory effect of quercetin platinum complex on tumor cell proliferation:

[0018] Take logarithmic growth phase human liver cancer HepG2, cervical cancer Hela and laryngeal cancer Hep2 cells and dilute them to 2×10 with RPMI-1640 medium containing 10% fetal bovine serum 6 / ml, inoc...

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Abstract

The invention relates to quercetin which has multiple aspects of biological activities, and has effects of phlegm elimination, asthma relief and antiatheroscloresis, etc., and has activities of fighting against the hyperplasia of various tumor cells; platinum complexes have obvious anticancer effect and the combination use of the quercetin and the cisplatin results in synergistic effects. In the invention, the quercetin reacts with a platinum compound under a certain condition for obtaining a quercetin platinum complex by being subjected to reversion, distill, chromatography and separation. The results from the MIT method experiment show that the quercetin platinum significantly inhibits the cell proliferation of tumors such as hepatoma HepG2, cervical carcinoma Hela and laryngocarcinoma Hep2, etc.

Description

Technical field [0001] The present invention belongs to chemical synthesis, and specifically relates to the synthesis method and application of quercetin platinum. Background technique [0002] Quercetin is a flavonoid compound widely distributed in plants. It is widely found in vegetables, fruits and Chinese herbal medicine. For example, allium, grapes and ginkgo all contain quercetin. Quercetin has the effects of expectorating, relieving cough and relieving asthma, as well as lowering blood pressure, reducing capillary fragility, lowering blood lipids, and dilating coronary arteries. Recent studies have shown that quercetin plays an important role in cancer prevention and treatment. The chemopreventive and therapeutic effects of quercetin on tumors have attracted more and more attention, making the research of quercetin and its derivatives enter a new stage. [0003] Quercetin can reduce DNA replication and cause delays in cell division. Quercetin inhibits the expression of c-m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30A61K31/352A61P35/00
Inventor 翟广玉王鹏王涛阚全程
Owner ZHENGZHOU UNIV
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