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Medicament composition and use thereof in preparing medicament for treating inflammation of eye section

A composition and drug technology, applied to the pharmaceutical composition of ocular inflammation, the field of treatment of ocular diseases, can solve the problems of combined use of prostaglandins, inability to obtain, etc., to overcome adverse reactions, overcome the increase in intraocular pressure, avoid The effect of elevated intraocular pressure

Inactive Publication Date: 2009-01-21
TIANJIN PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prior art believes that the synthesis and release of prostaglandins (PG) is an important cause of eye inflammation, and so far there is no combination of prostaglandins and glucocorticoids in the eyes to control the side effects of glucocorticoids. Therefore, it is impossible to draw inspiration from the prior art to combine prostaglandin drugs with glucocorticoids to reduce the side effects of glucocorticoid-induced intraocular pressure elevation

Method used

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  • Medicament composition and use thereof in preparing medicament for treating inflammation of eye section
  • Medicament composition and use thereof in preparing medicament for treating inflammation of eye section
  • Medicament composition and use thereof in preparing medicament for treating inflammation of eye section

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Travoprost 10mg

[0042] Hydrocortisone acetate 1.0g (particle size 5-20μm)

[0043] Sodium Carboxymethyl Cellulose 2.0g

[0044] Tween-80 0.8g

[0045] Sodium dihydrogen phosphate 4.55g

[0046] Disodium hydrogen phosphate 6.55g

[0047] Sodium chloride 4.0g

[0048] Ethylparaben 0.1g

[0049] Propylparaben 0.1g

[0050] Water for injection 1000ml

[0051] Dissolve the prescribed amount of ethylparaben and propylparaben in water for injection with 30% of the prescribed amount, heat to 80-90°C, add the prescribed amount of travoprost, Tween-80, dihydrogen phosphate Dissolve sodium, disodium hydrogen phosphate, and sodium chloride, filter with a No. 3 vertical melting funnel, and use it as solution, dissolve sodium carboxymethylcellulose in water for injection with 50% prescription volume, and use a pad with 200 Filter through a Buchner funnel of mesh nylon cloth, heat to 80-90°C, add the prescribed amount of hydrocortisone acetate and stir well, keep warm for 3...

Embodiment 2

[0053] Latanoprost 20mg

[0054] Hydrocortisone acetate 10g (particle size 5-20μm)

[0055] Sodium Carboxymethyl Cellulose 1.5g

[0056] Tween-80 1.0g

[0057] Sodium dihydrogen phosphate 7.9g

[0058] Sodium chloride 4.0g

[0059] Ethylparaben 0.15g

[0060] Propylparaben 0.15g

[0061] Water for injection 1000ml

[0062] Take 30% of the prescribed amount of water for injection, add the prescribed amount of sodium dihydrogen phosphate and sodium chloride to dissolve, adjust the pH to 6.5 with 1N sodium hydroxide solution, then add the prescribed amount of Tween-80 and paraben Ethyl ester, propylparaben, and latanoprost were filtered with No. 3 vertical melting funnel, and used as solution, sodium methylcellulose was dissolved in water for injection with 50% of the prescription volume, and a 200-mesh pad was used. Filter through a Buchner funnel of nylon cloth, heat to 80-90°C, add the prescribed amount of hydrocortisone acetate and stir well, keep warm for 30 minutes,...

Embodiment 3

[0064] Bimatoprost 100mg

[0065] Hydrocortisone acetate 10g (particle size 5-20μm)

[0066] Hydroxypropyl methylcellulose (non-ionic) 2.0g

[0067] Sodium dihydrogen phosphate 6.5g

[0068] Disodium hydrogen phosphate 5.2g

[0069] Sodium chloride 3.0g

[0070] 1N sodium hydroxide solution appropriate amount

[0071] Benzalkonium Chloride 0.25g

[0072] Dissolve the prescribed amount of benzalkonium chloride in 50% of the prescribed amount of water for injection, add the prescribed amount of sodium dihydrogen phosphate and sodium chloride to dissolve, adjust the pH to 6.8 with 1N sodium hydroxide solution, and then add the prescribed amount The amount of latanoprost was heated to 80-90°C to dissolve, cooled to room temperature, filtered with a No. 3 vertical melting funnel, and used as solution, hydroxypropyl methylcellulose was dissolved in 30% of the prescription amount for injection In water, filter with a Buchner funnel with 200-mesh nylon cloth, heat to 80-90°C, a...

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Abstract

The invention provides a pharmaceutical composition, in particular relating to a pharmaceutical composition for the treatment of eye diseases, especially eye inflammation. The pharmaceutical composition for the treatment of eye diseases consists of active ingredients and one or a plurality of accessories that are pharmaceutically acceptable, and is characterized in that the active ingredients of the pharmaceutical composition are one or a plurality of prostaglandin analogs and one or a plurality of glucocorticoids.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating eye diseases, especially eye inflammation. Background technique [0002] Glucocorticoids are steroid compounds secreted by the adrenal cortex, and their physiological effects are manifested in the effects on sugar, protein, fat, water and electrolytes. It can inhibit the synthesis and release of inflammatory mediators such as bradykinin, prostaglandin E2, serotonin, and histamine, reduce vascular permeability, stabilize lysosomal membranes, and inhibit phagocytosis. It has a strong anti-inflammatory effect on inflammation caused by various reasons, can reduce the exudation, edema, telangiectasia, leukocyte infiltration and phagocytosis in the early stage of inflammation, can inhibit the proliferation of capillaries and fibroblasts in the later stage of inflammation, and inhibit the immune system. The pathological changes produced by the re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/573A61K9/06A61P27/02A61K31/5575A61K31/496A61K31/5383A61K31/7036
Inventor 李静陈松张乐
Owner TIANJIN PHARMA GROUP CORP
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