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Dialdehyde starch crosslinked chitosan magnetic microsphere and preparation thereof

A technology of cross-linking chitosan and dialdehyde starch is applied in pharmaceutical formulations, medical preparations with non-active ingredients, anti-tumor drugs, etc. effect of dose

Inactive Publication Date: 2009-01-14
HEZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the literature reports that Fe 3 o 4 The particles are magnetic cores, and the magnetic microspheres are prepared by cross-linking chitosan with glutaraldehyde, epichlorohydrin, and polyethylene glycol. However, these linking agents themselves are highly toxic substances and are harmful to human health. restricted for medical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1), preparation of dialdehyde starch

[0017] Weigh 9 g of tapioca starch and 10 g of sodium periodate, and add 50 mL of water to dissolve them. Slowly add the sodium periodate solution dropwise into the aqueous starch solution, control the temperature at 40°C, control the pH to 2 with hydrochloric acid, stir magnetically for 4 hours in the dark, filter centrifugally, and wash with distilled water until the solution is neutral and no chloride ions are detected. Obtain dialdehyde starch.

[0018] (2), preparation of dialdehyde starch magnetic microspheres

[0019] Dissolve the prepared dialdehyde starch with 100% distilled water and place it in a 500mL round-bottomed flask. At a temperature of -40°C, add 150mL of a mixed solution of 0.6mol / L ferric chloride and ferrous chloride (Fe 2+ : Fe 3+ =1:2), quickly dropwise added 2mol / L ammonia water until the solution was black and bright, and stirred magnetically for 40 minutes to obtain dialdehyde starch magnetic microsph...

Embodiment 2

[0023] (1), preparation of dialdehyde starch

[0024] Weigh 10 g of tapioca starch and 11 g of sodium periodate, and add 50 mL of water to dissolve them. Slowly add the sodium periodate solution dropwise into the aqueous starch solution, control the temperature at 40°C, control the pH to 2 with hydrochloric acid, stir magnetically for 6 hours under dark conditions, centrifugally filter, and wash with distilled water until the solution is neutral and no chloride ions are detected. Obtain dialdehyde starch.

[0025] (2), preparation of dialdehyde starch magnetic microspheres

[0026] Dissolve the prepared dialdehyde starch with 100°C of distilled water and place it in a 500mL round-bottomed flask. At a temperature of 40°C, add 150mL of a mixed solution of 0.6mol / L ferric chloride and ferrous chloride (Fe 2+ : Fe 3+ =1:2), quickly dropwise added 2mol / L ammonia water until the solution was black and bright, and stirred magnetically for 40 minutes to obtain dialdehyde starch mag...

Embodiment 3

[0030] (1), preparation of dialdehyde starch

[0031] Weigh 11g of tapioca starch and 14g of sodium periodate, add 50mL of water to dissolve respectively. Slowly add the sodium periodate solution dropwise into the aqueous starch solution, control the temperature at 40°C, control the pH to 2 with hydrochloric acid, stir magnetically for 8 hours under dark conditions, centrifugally filter, and wash with distilled water until the solution is neutral and no chloride ions are detected. Obtain dialdehyde starch.

[0032] (2), preparation of dialdehyde starch magnetic microspheres

[0033] Dissolve the prepared dialdehyde starch with 100°C of distilled water and place it in a 500mL round-bottomed flask. At a temperature of 40°C, add 150mL of a mixed solution of 0.6mol / L ferric chloride and ferrous chloride (Fe 2+ : Fe 3+ =1:2), quickly dropwise added 2mol / L ammonia water until the solution was black and bright, and stirred magnetically for 40 minutes to obtain dialdehyde starch ma...

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Abstract

The invention relates to diadehyde starch cross-linking chitosan magnetic microsphere and the preparation method, and the diadehyde starch cross-linking chitosan magnetic microsphere belongs to the functional macromolecule material. The preparation method comprises the following steps: firstly, the diadehyde starch is prepared; secondly, the diadehyde starch cross-linking magnetic microsphere is prepared; and thirdly, the diadehyde starch cross-linking chitosan magnetic microsphere is prepared. The diadehyde starch cross-linking chitosan magnetic microsphere uses the magnetic microsphere prepared through the cross-linking reaction of the chitosan and the diadehyde starch, the magnetic microsphere has no toxic side effect to the human body. The diadehyde starch cross-linking chitosan magnetic microsphere prepared through the invention is used for the targeting drug carrier, and the diadehyde starch cross-linking chitosan magnetic microsphere contains a large quantity of aldehyde groups, which is convenient for the combination of the amino groups in the drug, thereby enhancing the drug carrying amount, and simultaneously after the drug arrives at the lesion location, which can be easily combined with the proteases in the human body, to fully exert the drug effect.. The diadehyde starch cross-linking chitosan magnetic microsphere and the preparation methodare particularly suitable for the treatment to the tumour.

Description

technical field [0001] The invention belongs to the field of functional polymer materials, and relates to a dialdehyde starch cross-linked chitosan magnetic microsphere and a preparation method thereof. Background technique [0002] The study of magnetic nano-medicine polymer carrier microspheres began in the 1980s. In addition to the good spheroidization of polymers, it also has good surface effects, volume effects, magnetic effects, biocompatibility and functional group properties. . It has good application prospects in immobilized enzymes, targeted drug delivery, cell separation, medical detection and immune analysis, especially in tumor treatment. Chitosan is often used as materials such as artificial skin and wound dressing because of its good biological activity, biocompatibility, biodegradability and other biological functions. So far, the literature reports that Fe 3 o 4 The particles are magnetic cores, and the magnetic microspheres are prepared by cross-linking...

Claims

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Application Information

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IPC IPC(8): C08J3/00C08J3/24C08L3/04C08L5/08C08K3/22A61K47/36A61P35/00
Inventor 梁柏林张娜赵小红黄华
Owner HEZHOU UNIV
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