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Process for the preparation of 3-hydroxypropanal method for preparing 3-hydroxyl propionaldehyde

A technology of hydroxypropionaldehyde and culture medium, applied in the field of preparation of 3-hydroxypropionaldehyde, can solve problems such as troublesome separation, achieve the effects of reducing conversion time, improving raw material utilization rate and production efficiency, and saving cost

Inactive Publication Date: 2008-12-31
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, 3-hydroxypropionaldehyde is an intermediate product of Klebsiella metabolizing glycerol, and generally does not secrete out of the cell. Therefore, the methods disclosed in the above patents all need to add semicarbazide hydrochloride during the fermentation process to regulate the metabolic process, while Semicarbazide hydrochloride will react with 3-hydroxypropanal to form a complex, so what is obtained after fermentation is not 3-hydroxypropanal monomer, and the subsequent separation is extremely troublesome, and there is no public report yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) Strain: Lactobacillus reuteri HQU001

[0021] (2) culture medium

[0022] Solid slant medium: beef protein powder 10g, fish juice 10g, yeast extract juice powder 5g, glucose 20g, sodium acetate 5g, diammonium citrate 2g, Tween 80 0.1g, magnesium sulfate 0.58g, manganese sulfate 0.28g, agar 18g , distilled water 1000ml. Adjust the pH to 5.4 with acetic acid.

[0023] Seed medium: beef protein powder 10g, fish juice 10g, yeast extract juice powder 5g, glucose 20g, sodium acetate 5g, diammonium citrate 2g, Tween 80 0.1g, magnesium sulfate 0.58g, manganese sulfate 0.28g, distilled water 1000ml. Adjust the pH to 5.4 with acetic acid.

[0024] Fermentation medium: beef protein powder 10g, fish juice 10g, yeast extract juice powder 5g, glucose 25g, glycerin 20g, sodium acetate 5g, diammonium citrate 2g, Tween 80 0.1g, magnesium sulfate 0.58, manganese sulfate 0.28, distilled water 1000ml . Adjust the pH to 5.4-6.5 with acetic acid.

[0025] (3) Cultivation

[0026] ...

Embodiment 2

[0030] (1) Strain: Lactobacillus reuteri HQU001

[0031] (2) culture medium

[0032] Solid slant medium: beef protein powder 5g, fish juice 5g, yeast extract juice powder 3g, glucose 10g, sodium acetate 3g, diammonium citrate 1g, Tween 80 0.1g, magnesium sulfate 0.2g, manganese sulfate 0.1g, agar 15g , distilled water 1000ml. Adjust the pH to 5 with acetic acid.

[0033] Seed medium: beef protein powder 5g, fish juice 5g, yeast extract juice powder 3g, glucose 10g, sodium acetate 3g, diammonium citrate 1g, Tween 80 0.1g, magnesium sulfate 0.2g, manganese sulfate 0.1g, distilled water 1000ml. Adjust the pH to 5 with acetic acid.

[0034] Fermentation medium: beef protein powder 5g, fish juice 5g, yeast extract juice powder 3g, glucose 10g, glycerol 10g, sodium acetate 3g, diammonium citrate 1g, Tween 800.1g, magnesium sulfate 0.2g, manganese sulfate 0.1g, distilled water 1000ml. Adjust the pH to 5 with acetic acid.

[0035] (3) Cultivation

[0036] Cultivation of Lactoba...

Embodiment 3

[0040] (1) Strain: Lactobacillus reuteri HQU001

[0041] (2) culture medium

[0042] Solid slant medium: beef protein powder 20g, fish juice 20g, yeast extract juice powder 7g, glucose 30g, sodium acetate 7g, diammonium citrate 3g, Tween 80 0.3g, magnesium sulfate 1g, manganese sulfate 0.5g, agar 25g, Distilled water 1000ml. Adjust the pH to 6 with acetic acid.

[0043] Seed medium: beef protein powder 20g, fish juice 20g, yeast extract juice powder 7g, glucose 30g, sodium acetate 7g, diammonium citrate 3g, Tween 80 0.3g, magnesium sulfate 1g, manganese sulfate 0.5g, distilled water 1000ml. Adjust the pH to 6 with acetic acid.

[0044] Fermentation medium: beef protein powder 20g, fish juice 20g, yeast extract juice powder 7g, glucose 30g, glycerol 30g, sodium acetate 7g, diammonium citrate 3g, Tween 80 0.3g, magnesium sulfate 1g, manganese sulfate 0.5g, distilled water 1000ml. Adjust the pH to 7 with acetic acid.

[0045] (3) Cultivation

[0046] Cultivation of Lactoba...

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Abstract

The invention discloses a process for preparing 3-hydroxy-propionaldehyde, which adopts a two-stage process of cultivating microbial thalli firstly and then utilizing the thalli to transform glycerol, and the process comprises the following steps of: (1) preparing an MRS culture medium containing glucose or fructose for cultivating microorganisms that contain glycerol anhydrase and can secrete the 3-hydroxy-propionaldehyde to the outside of cells, and acquiring mass thalli; and (2) utilizing the thalli to serve as a biocatalyst for transforming the glycerol so as to produce the 3-hydroxy-propionaldehyde. The process has advantages of simple separation process, only needing the thalli separation in the transformation process, having no byproduct, saving separation and purification costs, reusable thalli after filtration, washing and activation, reducing the transformation time and improving the production efficiency.

Description

technical field [0001] The invention relates to a preparation method of 3-hydroxypropanal. Background technique [0002] As we all know, 3-hydroxypropionaldehyde is an important chemical raw material, which can be used as the precursor of various emerging chemicals such as acrolein, acrylic acid, 1,3-propanediol, etc., for the preparation of new polymer materials. 3-Hydroxypropionaldehyde can be chemically oxidized to produce acrylic acid, which is generally obtained from the petroleum industry and can be used to produce acrylate, polyacrylic acid and acrylate, etc.; 3-Hydroxypropionaldehyde can be catalyzed to generate 1,3-propanediol, 1, Polyester PPT (polytrimethylene terephthalate) synthesized from 3-propanediol and terephthalic acid has incomparable advantages in chemical stability, colorability, textile printing and dyeing characteristics and biodegradability, and has become an international synthetic Hotspots for fiber development. At the same time, it has been conf...

Claims

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Application Information

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IPC IPC(8): C12P7/24C12R1/225C12R1/01
Inventor 陈国方柏山肖雅琴
Owner HUAQIAO UNIVERSITY
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