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Compound branched chain amino acid injection

A branched-chain amino acid and injection technology, which is applied in the fields of medical formula, metabolic diseases, organic active ingredients, etc., and can solve the problems that patients cannot achieve nutritional effects

Active Publication Date: 2008-12-31
MITSUBISHI PHARMA GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The amino acid infusions of these formulas are all based on the human body’s demand for amino acids under normal physiological conditions, but the ideal nutritional effect is often not achieved for patients under stress.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Dissolve the following components in distilled water for injection according to the following parts by weight, adjust the pH value of the amino acid solution to neutral, put the solution into a bottle or plastic bag after sterilization and filtration, fill it with nitrogen and seal it, and heat it out according to the conventional method Bacteria, make the present embodiment injection.

[0090] L-Isoleucine 8.5

[0091] L-leucine 12.2

[0092] L-valine 18.5

[0093] L-Lysine 7.0

[0094] L-Methionine 3.5

[0095] L-phenylalanine 6.5

[0096] L-Threonine 5.0

[0097] L-Tryptophan 1.1

[0098] L-alanine 8.0

[0099] L-Arginine 11.5

[0100] L-Aspartic acid 0.2

[0101] L-histidine 3.9

[0102] L-glutamic acid 0.1

[0103] L-proline 3.9

[0104] L-serine 2.5

[0105] L-tyrosine 0.1

[0106] Glycine 8.0

[0107] L-cysteine ​​0.2

[0108] Table 1 is the comparison of the branched-chain amino acid ratio and E / N value between this example and compound amino aci...

Embodiment 2

[0112] Prepare the following components and parts by weight of the injection according to the method of Example 1.

[0113] L-Isoleucine 14.0

[0114] L-leucine 17.5

[0115] L-valine 13.7

[0116] L-Lysine 10.0

[0117] L-Methionine 6.0

[0118] L-phenylalanine 7.5

[0119] L-threonine 6.5

[0120] L-Tryptophan 1.9

[0121] L-alanine 6.0

[0122] L-Arginine 8.5

[0123] L-Aspartic Acid 1.0

[0124] L-Histidine 5.5

[0125] L-glutamic acid 0.6

[0126] L-Proline 6.5

[0127] L-Serine 1.0

[0128] L-tyrosine 0.4

[0129] Glycine 5.0

[0130] L-cysteine ​​0.4

[0131] Table 2 is the comparison of the branched-chain amino acid ratio and E / N value between this example and compound amino acid injection (18AA) and compound amino acid injection (18AA-I).

[0132] Table 2 Comparison of branched-chain amino acid ratios and E / N values ​​in three injections

[0133] Compound Amino Acid Injection

Embodiment 3

[0135] Prepare the following components and parts by weight of the injection according to the method of Example 1.

[0136] L-Isoleucine 8.8

[0137] L-leucine 12.5

[0138] L-valine 13.5

[0139] L-Lysine 9.7

[0140] L-Methionine 4.3

[0141] L-phenylalanine 6.7

[0142] L-threonine 5.8

[0143] L-Tryptophan 1.2

[0144] L-alanine 6.9

[0145] L-Arginine 8.7

[0146] L-Aspartic Acid 0.9

[0147] L-histidine 4.8

[0148] L-glutamic acid 0.5

[0149] L-proline 4.8

[0150] L-serine 1.6

[0151] L-tyrosine 0.3

[0152] Glycine 6.7

[0153] L-cysteine ​​0.3

[0154] Table 3 is the comparison of the ratio and E / N value of branched-chain amino acids in this example and compound amino acid injection (18AA) and compound amino acid injection (18AA-I).

[0155] Table 3 Comparison of branched-chain amino acid ratios and E / N values ​​in three kinds of injections

[0156] Compound Amino Acid Injection

(18AA)

Compound Amino Acid Injection

(18AA-...

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PUM

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Abstract

The present invention provides a compound branched chain amino acid injection. The injection provided by the present invention increases the weight parts of the branched chain amino acid to lead the weight parts within 35 to 50 percent of the total amount of amino acid and effectively keeps a nitrogen balance of the organism; the prescription ratio of necessary amino acid and unnecessary amino acid is increased to about 1.7, thus better recovering the inordinate plasma amino acid spectrum of the organism in trauma to the normal range and achieving the ideal nutritious effect on the patient under the stress state.

Description

technical field [0001] The invention relates to a compound amino acid, in particular to a compound branched-chain amino acid injection. Background technique [0002] When a patient is stressed by strong stimuli such as major surgery, burns, trauma, infection, and progressive cancer, the various functions and metabolism of the patient will change, a large amount of decomposing hormones will be secreted in the body, the body tissue is in a state of self-decomposition, and the metabolism is serious. disorder. At this time, nutritional support must be given to the patient, and various nutritional elements, including amino acid injection, must be given to compensate for the body consumption caused by high metabolic rate and enhanced protein decomposition during stress. [0003] The difference in the composition of amino acids in amino acid injections not only has a great impact on the nutritional indicators of protein metabolism in patients, but also has a significant impact on ...

Claims

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Application Information

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IPC IPC(8): A61K31/4172A61P3/02A61K31/198A61K31/401A61K31/405
Inventor 古川正人
Owner MITSUBISHI PHARMA GUANGZHOU
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