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Preparation of nifuratel and nysfungin vaginal soft capsules

A technology of nifuratel nystatin and nifuratel, which is applied in the direction of medical preparations containing active ingredients, pill delivery, organic active ingredients, etc., and can solve problems such as increased glycogen content, bacterial mutation, and human hazards , to achieve the effect of high effective drug concentration, promoting disease recovery, and convenient use

Inactive Publication Date: 2008-12-31
李国栋
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  • Abstract
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Problems solved by technology

[0003] At present, the most common drugs used clinically are metronidazole (metrodiazole) and antibiotics. Among them, metronidazole has a good effect on trichomonas and anaerobic infection, but the drug is easy to enter the fetus through the placenta, and is harmful to rodents. Animals have carcinogenic effects and also have mutagenic effects on bacteria, so they are harmful to humans or can cause teratogenicity. Pregnant women should use them with caution. Pregnancy is a period of high incidence of vaginal infections. The reason is that cellular immune function declines and estrogen increases The glycogen content in the vaginal epithelium increases, which becomes a medium conducive to the growth of bacteria and accelerates the reproduction of pathogenic bacteria

Method used

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  • Preparation of nifuratel and nysfungin vaginal soft capsules
  • Preparation of nifuratel and nysfungin vaginal soft capsules
  • Preparation of nifuratel and nysfungin vaginal soft capsules

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Embodiment

[0022] Example: 500 g of nifuratel, 200,000 units of nystatin, 60 g of lactose, 100 g of starch, 100 g of kaolin, 60 g of calcium lactate, 82 g of lactic acid, 30.0 g of silicon dioxide, 100 g of microcrystalline cellulose, and crospovidone 120g (plus 40g), povidone K 30 6g, Tween-80 0.5g magnesium stearate 6.0g to make 1000 tablets.

[0023] (2) Method

[0024] A Pretreatment: In addition to nystatin and lactic acid, nifuratel, lactose, starch, kaolin, calcium lactate, silicon dioxide, microcrystalline cellulose, crospovidone, and magnesium stearate were passed through the number sieve.

[0025] B Nifuratel Nystatin Vaginal Tablet Granule Preparation: Take by weighing the prescribed amount of Nifuratel, Nystatin and lactose, starch, kaolin, calcium lactate, lactic acid, microcrystalline cellulose, crospovidone 80g , with povidone K 30 Ethanol solution is used as binder, granulated with 16 mesh, dried at 60-70°C, granulated with 16 mesh sieve, sprayed with Tween-80 ethano...

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Abstract

The present invention relates to preparation of a new medicine Nifuratel nysfungin vagina tablet for gynecologic antisepsis and anti-inflammation. Nifuratel nysfungin can play a more complete role in curing mixed vagina infection (candida, trichomonas and bacteria) and pathogen which can not be or can not be timely and clearly diagnosed and preventing mildew secondary infection and recurrence after the treatment of other medicines. The present invention can be used for curing bacterial vaginopathy, trichomonas vaginitis, monilial vulvovaginitis, and vagina mixed infection. The advantage of the present invention lies in that the added pH buffer system ensures pH of the medicine is within 3.5 to 4.0 close to the physiological pH of vagina, thus effectively protecting the physiological environment of vagina, providing the appropriate living conditions beneficial to flora in vagina and promoting the recovery of diseases.

Description

technical field [0001] The invention relates to the preparation of a new antibacterial and anti-inflammatory drug nifuratel nystatin vaginal tablet for gynecology. Background technique [0002] Bacterial vaginosis (BV) and vaginal trichomoniasis are common multiple-occurring diseases in obstetrics and gynecology. Hurley et al. reported that about 75% of women of childbearing age had one episode of BV, and about 5% had recurrent episodes. Worldwide There are more than 200 million people infected with Trichomonas vaginalis. BV often coexists with Trichomonas vaginitis. It has been reported that 86% of women with positive trichomonas culture have BV. There are also domestic surveys showing that among 227 gynecological outpatients with increased vaginal discharge or peculiar smell, 120 cases were BV patients, accounting for 43.33%, and 19.17% of them were combined with trichomonas infection (23 / 120); 36 cases of trichomonas vaginitis ( 13%), 31 cases (11.1%) of candidal vaginit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/422A61K31/7048A61P15/02
Inventor 李国栋
Owner 李国栋
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