Recognition method of highly pathogenic avian influenza virus hemagglutinin protein

Abstract

The invention discloses a highly-pathogenic avian influenza virus hemagglutinin protein identification method, which can be used for highly-pathogenic avian influenza virus hemagglutinin protein identification and provide a reference for understanding the structural characteristics of the highly-pathogenic avian influenza virus hemagglutinin protein; through the identification of the hemagglutinin protein, the method can indirectly distinguish the degree of the pathogenicity of the avian influenza virus strain to which the hemagglutinin protein belongs. The method comprises the following steps: a), to establish an amino acid holographic topological structure score vector, based on principal component analysis; b), to apply the amino acid holographic topological structure score vector to characterize the structure of the influenza virus hemagglutinin protein; c), to carry out normalized processing to the characteristic variable of each influenza virus hemagglutinin protein through a self-cross-covariance method; d), to establish an avian influenza virus hemagglutinin protein identification model through an RBF kernel-based support vector machine; e), to establish a highly-pathogenic avian influenza virus hemagglutinin protein identification model through the RBF kernel-based support vector machine.

Description

technical field [0001] The invention relates to a method for identifying influenza virus hemagglutinin protein, in particular to a method for identifying highly pathogenic avian influenza virus hemagglutinin protein. Background technique [0002] Influenza belongs to the Orthomyxoviridae family, which can be divided into three types: A, B and C. Avian influenza is a disease syndrome in poultry caused by influenza A virus. According to different pathogenicity, avian influenza virus (AIV) can be divided into non-pathogenic, low pathogenicity and high pathogenicity strains. Most of the non-pathogenic and low-pathogenic strains are subclinical infection or mild symptoms, and do not cause serious disease or death. Highly pathogenic avian influenza virus (HPAIV) spreads quickly and is highly lethal. It has a high lethality rate to poultry and is easily mutated and can infect humans. From January 2003 to June 19, 2008, the cumulative number of laboratory-confirmed human cases of...

AI Technical Summary

Problems solved by technology

However, the above experimental methods to detect highly pathogenic avian influenza viruses are time-consuming, laborious and expensive

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