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Magnetic resonance method for the detection and imaging of susceptibility related magnetic field distortions

A magnetic susceptibility, magnetic resonance imaging technology, applied in the measurement of magnetic variables, measurement devices, instruments, etc., can solve problems such as false positives, background signal enhancement, and limited practical applications

Inactive Publication Date: 2008-11-05
UNIVERSITY OF BASEL
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Problems solved by technology

Methods in the prior art often suffer from unwanted background signal enhancement, which limits their practical application for MR-guided clinical interventions, cell tracking and / or molecular imaging
In particular, enhancement of those unwanted background signals leads to false positives, which may have a considerable negative impact on patient safety

Method used

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  • Magnetic resonance method for the detection and imaging of susceptibility related magnetic field distortions
  • Magnetic resonance method for the detection and imaging of susceptibility related magnetic field distortions
  • Magnetic resonance method for the detection and imaging of susceptibility related magnetic field distortions

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Embodiment Construction

[0018] For a more complete understanding of the invention and its advantages, the following description of various illustrative and non-limiting embodiments is set forth together with the accompanying drawings, in which like reference numbers indicate like features.

[0019] Magnetic resonance imaging, hereafter referred to as "MRI" (and more commonly referred to as nuclear magnetic resonance imaging or "NMR"), is a method of producing images that employs the detection of the relaxation properties of excited atomic nuclei, which are then exposed to Pulses of electromagnetic energy (excitation / gradient pulses, radio frequency or "RF" pulses) are used in order to force atomic nuclei into temporarily assumed non-aligned higher energy states. In such methods, changes in the energy state as the energy state is affected by the application of magnetic and RF fields are measured and / or detected and then incorporated into an image.

[0020] Although images produced by known MRI techniq...

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Abstract

Disclosed are methods and apparatuses for generating susceptibility-related contrast images, as induced, e.g., by marker material interventional devices used for passive MR-guided interventions, or by particles or cells loaded with marker materials used for molecular imaging, cell-tracking or cell-labeling. Near a local magnetic field perturber a positive contrast signal emanates from local gradient compensation to form, e.g., a balanced SSFP type of echo, whereas everywhere else echoes are shifted outside of the data acquisition window.

Description

technical field [0001] The present invention relates to methods and devices for imaging magnetic field distortions associated with susceptibility, e.g. caused by marker materials of interventional devices, or by loading (laden) particles or cells . In certain embodiments, the present invention relates to methods and apparatus for generating a positive signal from such local magnetic field distortions, the background of which is used to track and / or visualize during a Magnetic Resonance Imaging (MRI) scan Interventional device, or for visualization and / or detection of local field inhomogeneities eg produced by iron-bearing particles or cells. Background technique [0002] Magnetic susceptibility-induced contrast produced by marking materials (eg paramagnetic materials) has gained increasing interest in MRI due to their widespread application. These applications include, but are not limited to, cell tracking, molecular imaging, or in interventional MRI, for example, guidance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/565
CPCG01R33/5614G01R33/286G01R33/5613
Inventor 奥利弗·比厄里克劳斯·舍费尔
Owner UNIVERSITY OF BASEL
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