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Method for preparing biological activity glass nano-fibre cluster

A bioactive glass and nanofiber technology is applied in the field of inorganic powder preparation in the field of biomedical materials, and can solve the problems of easy introduction of impurities and the like

Inactive Publication Date: 2008-10-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Bioactive glass is an important bioactive material, but most of the bioactive glass particles prepared by the traditional high-temperature melting method are micron-sized, and impurities are easily introduced during the preparation process

Method used

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  • Method for preparing biological activity glass nano-fibre cluster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) First prepare a certain amount of ethyl orthosilicate and triethyl phosphate into solution A; mix a certain amount of calcium nitrate tetrahydrate, hydrochloric acid, deionized water, and Tween template into solution B, and adjust with hydrochloric acid The pH of the solution is 1, and the template concentration is 0.5×10 -2 mol / L; Slowly add B solution to A solution and stir well to obtain a transparent, uniform and stable sol; Among them, ethyl orthosilicate, triethyl phosphate and calcium nitrate tetrahydrate account for the total moles of the three substances The percentages are respectively 60%, 4% and 36%, and the molar ratio of deionized water to ethyl orthosilicate is 12:1;

[0021] (4) The sol obtained in step (3) is statically aged for 4 days at room temperature to allow the hydrolysis-polycondensation reaction to proceed sufficiently to form a wet gel;

[0022] (5) Put the wet gel obtained in step (4) in a drying oven at 140°C for 2 days, and obtain a dry gel...

Embodiment 2

[0025] (1) First prepare a certain amount of ethyl orthosilicate and triethyl phosphate into solution A; mix a certain amount of calcium nitrate tetrahydrate, hydrofluoric acid, deionized water, and Tween template into solution B, use Hydrofluoric acid adjusts the pH of the solution to 3, and the template concentration is 1.5×10 -2 mol / L; Slowly add B solution to A solution and stir well to obtain a transparent, uniform and stable sol; Among them, ethyl orthosilicate, triethyl phosphate and calcium nitrate tetrahydrate account for the total moles of the three substances The percentages are 70%, 4% and 26% respectively, and the molar ratio of deionized water to ethyl orthosilicate is 11:1;

[0026] (4) The sol obtained in step (3) is statically aged for 5 days at room temperature to allow the hydrolysis-polycondensation reaction to proceed sufficiently to form a wet gel;

[0027] (5) Place the wet gel obtained in step (4) in a drying oven at 80°C for 3 days, and obtain a dry gel af...

Embodiment 3

[0030] (1) First prepare a certain amount of ethyl orthosilicate and triethyl phosphate into solution A; mix a certain amount of calcium nitrate tetrahydrate, ammonia, deionized water, and Tween template into solution B, and use alkaline The catalyst adjusts the pH value of the solution to 10, and the template concentration is 3×10 -2 mol / L; Slowly add B solution to A solution and stir well to obtain a transparent, uniform and stable sol; Among them, ethyl orthosilicate, triethyl phosphate and calcium nitrate tetrahydrate account for the total moles of the three substances The percentages are respectively 80%, 4% and 16%, and the molar ratio of deionized water to ethyl orthosilicate is 8:1;

[0031] (4) The sol obtained in step (3) is statically aged for 7 days at room temperature to allow the hydrolysis-polycondensation reaction to proceed sufficiently to form a wet gel;

[0032] (5) Put the wet gel obtained in step (4) in a drying oven at 100°C for 2 days, and dry gel is obtaine...

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Abstract

The invention relates to a preparation method of a bioactive glass nanofiber cluster, which is characterized in that A solution which is composed of tetraethyl orthosilicate and triethyl phosphate and B solution which is composed of calcium nitrate tetrahydrate, deionized water, a template agent and a catalyst are firstly prepared, the B solution is slowly dropped into the A solution to form a sol, the sol forms a gel by aging for 4 to 7 days, the gel is dried for 2 to 3 days at the temperature of 80 to 140 DEG C, and finally the nanofiber cluster material is obtained by heat treatment and solidification process at 400 to 700 DEG C and grinding. The weight percentage of the components of the nanofiber cluster is that: 60 to 80 percent of SiO2, 36 to 16 percent of CaO and 4 percent of P2O5. The bioactive glass nanofiber cluster prepared by the invention is composed of nano-fibers that are regularly arranged, thus showing good biological mineralization characteristics in simulated physiological solution and being used in the fields such as bone tissue repair and bone tissue engineering.

Description

Technical field [0001] The invention relates to a method for preparing inorganic powder in the field of biomedical materials, in particular to a method for preparing bioactive glass nanofiber clusters. Background technique [0002] Bioactive glass is an important bioactive material, but most of the bioactive glass particles prepared by the traditional high-temperature melting method are of the micron level, and impurities are easily introduced during the preparation process. The bioactive glass prepared by the sol-gel method has a special nano-microstructure, high specific surface area, adjustable composition and structure, and chemical uniformity at the molecular level. The material has good biomineralization properties in simulated physiological solutions. Cytology and animal experiments also show that it has good bone repair ability. The template self-assembly process is a process technology for preparing special nanomaterials. The inorganic components contained in natural bon...

Claims

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Application Information

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IPC IPC(8): A61L27/10
Inventor 陈晓峰郭常亮赵娜如王迎军
Owner SOUTH CHINA UNIV OF TECH
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