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Antibacterial gynecology externally used pharmaceutical combination

A technology of externally used drugs and compositions, applied in the field of medicine, can solve problems such as lack of therapeutic effect and stability problems, and achieve good therapeutic effect, good stability, and good antibacterial effect

Active Publication Date: 2012-01-25
万全万特制药(厦门)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although compound preparations have expanded antibacterial spectrum, many ingredients may cause stability problems
In addition, high-acid vaginitis is closely related to fungal vaginitis, and many fungal vaginitis is combined with high-acid vaginitis, which is why it is difficult to cure recurrent attacks with antifungal drugs alone.
Therefore, simply expanding the antibacterial spectrum and using multiple active ingredients in combination will not achieve good therapeutic effects.

Method used

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  • Antibacterial gynecology externally used pharmaceutical combination
  • Antibacterial gynecology externally used pharmaceutical combination
  • Antibacterial gynecology externally used pharmaceutical combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The present embodiment is a suppository.

[0016]

[0017] Preparation method: Weigh the prescription amount of PEG-4000, PEG-6000, glycerin and water on a water bath to heat and melt; weigh the prescription amount of butoconazole nitrate and sodium lactate into the molten matrix, mix well; pour into the mold while it is hot Medium; let it cool, open the mold and take it out after it is completely solidified.

Embodiment 2

[0019] The present embodiment is a vaginal tablet.

[0020]

[0021] Preparation:

[0022] Weigh the prescription amount of butoconazole nitrate, sodium lactate, microcrystalline cellulose, mannitol and a part of crospovidone and mix them uniformly; add the aqueous solution of povidone to the mixture to granulate. 50℃ blast drying, whole grain. Mix the two sets of dry particles, add the remaining part of crospovidone and magnesium stearate, and mix well. Check the particle content, press the tablet, and that's it.

Embodiment 3

[0023] Example 3 This example is in the form of vaginal effervescent tablets.

[0024]

[0025] Preparation:

[0026] Weigh the prescription amount of butoconazole nitrate, mannitol and sodium bicarbonate and mix uniformly to obtain mixture 1; weigh the prescription amount of microcrystalline cellulose and citric acid and mix homogeneously to obtain mixture 2; add polyvinyl chloride to mixtures 1 and 2 respectively Aqueous solution of ketone, granulation. 50℃ blast drying, whole grain. Mix two sets of dry granules, add magnesium stearate, and mix well. Check the particle content, press the tablet, and that's it.

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PUM

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Abstract

The invention discloses an external gynecological drug compound which consists of an active ingredient butoconazole nitrate and other drug carriers acceptable in pharmacy. The external gynecological drug compound has the forms of suppositories, vaginal tablets and vaginal effervescent tablets and can be used for treating the fungal infection outside the vagina caused by mycotoruloides.

Description

Technical field [0001] The invention relates to an antibacterial gynecological external medicine composition, which belongs to the technical field of medicine. Background technique [0002] Fungal vaginitis is one of the three common vaginal diseases in women (the other two are bacterial vaginosis and trichomonas vaginitis). It has a high incidence and is difficult to cure. Butoconazole nitrate is an imidazole antifungal drug, its antibacterial effect on Candida albicans is equal to or better than other imidazole derivatives such as clotrimazole, miconazole and nystatin. Its clinical cure rate of 3 days and 8 days is 80% and 95%, which is significantly better than clotrimazole. The treatment course is short, side effects are small, and it is well tolerated. [0003] At present, KV Pharmaceutical of the United States has marketed butoconazole nitrate cream under the trade name . The drug in the mouth of the cream is easily contaminated when used repeatedly, and the dosage of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4164A61K9/02A61K9/20A61K9/46A61K47/02A61K47/12A61K47/38A61P31/02A61P15/02
Inventor 袁筝
Owner 万全万特制药(厦门)有限公司
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