Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Abuterluo tablet for treating chronic liver fibrosis and preparation technique thereof

A preparation process and oral tablet technology, which is applied in the digestive system, active ingredients of hydroxyl compounds, pill delivery, etc., can solve the problems that have not been seen in the preparation process and method of Abterlo tablets

Inactive Publication Date: 2008-09-10
黄兆胜
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But up to now, have not seen the preparation technology and the method of Abterol tablet yet, the present invention also proposes to use microcrystalline cellulose, cross-linked polyvinyl pyrrolidone, cross-linked sodium carboxymethyl cellulose, poloxane for the first time. The method of preparing Abuterol tablets using thiamine as an excipient, which improves the water solubility of this type of drug, makes the preparation disintegrate rapidly and uniformly disperse, thereby improving the dissolution rate and bioavailability of the drug, and playing a therapeutic role more effectively

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0033] Resveratrol 50g

[0034] Lactose 30g

[0035] Microcrystalline Cellulose 28g

[0036] Cross-linked polyvinylpyrrolidone 4g

[0037] Poloxamer 6g

[0038] Magnesium stearate 0.5g

[0039] 30% ethanol 45ml

[0040] Makes 1000 pieces

[0041]

example 2

[0043] Resveratrol 50g

[0044] Lactose 30g

[0045] Microcrystalline Cellulose 30g

[0046] Microphenol Silica Gel 10g

[0047] Cross-linked polyvinylpyrrolidone 5g

[0048] Poloxamer 6g

[0049] Magnesium stearate 0.5g

[0050] 30% ethanol 45ml

[0051]

[0052] Makes 1000 pieces

example 3

[0054] Resveratrol 50g

[0055] Lactose 30g

[0056] Microcrystalline Cellulose 30g

[0057] Micronized silica gel 10g

[0058] Cross-linked polyvinylpyrrolidone 5g

[0059] Croscarmellose Sodium 5g

[0060] Poloxamer 6g

[0061] Magnesium stearate 0.5g

[0062] 30% ethanol 45ml

[0063]

[0064] Makes 1000 pieces

[0065] Preparation process in the above example

[0066] 1. Fully mix the main drug (raw material) with fillers, disintegration aids, binders, surfactants and 2 / 3 disintegrants, and grind them in a high-speed mill for micronization treatment to obtain extremely Fine powder (200 mesh).

[0067] 2. Make the above ultra-fine powder into soft material with wetting agent, granulate with 18 mesh sieve, and dry below 80°C for 4 hours.

[0068] 3. Mix the other 1 / 3 amount of disintegrant and wetting agent into the dry granules, and sieve the granules with a 16-mesh sieve.

[0069] 4. Tablet pressing, the pressure is 2.5-3.0kg / c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
Login to View More

Abstract

The invention relates to an Abuteluo tablet used or curing hepatic fibrosis caused by chronic hepatitis and a preparation method thereof, pertaining to the field of medicine and preparation technique of medicine. The Abuteluo tablet comprises medicines by weight portion: 1 portion of resveratrol taken as raw material drug and 0.2 portion of co-disintegrant, 0.08-0.2 portion of disintegrant, 0.1-0.12 portion of surfactant and 0.5-0.6 portion of adhesive which are taken as auxiliary materials. The Abuteluo tablet can swell and disperse quickly in water to lead the resveratrol to dissolve quickly, so that the dissolubility and the bioavailability of the Abuteluo tablet are greatly improved, ensuring the effective curative function. The technical problem that the invention aims at solving is to provide a tablet with good curative effect and high bioavailability to cure the hepatic fibrosis caused by chronic hepatitis and a preparation method thereof.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and its preparation process, in particular to an oral tablet capable of treating liver fibrosis caused by chronic hepatitis and its preparation process. technical background [0002] Hepatitis B virus (HBV) has the characteristics of strong infectivity and high incidence, and it is distributed worldwide. my country is one of the high prevalence areas of hepatitis B. Chronic hepatitis B is a major disease that affects the health of our people. Because of its characteristics of "healthy" infection and chronic process, it is not easy to be controlled in the crowd and spread to the world. Sexually transmitted diseases are social public health problems worldwide. [0003] Fibrous hyperplasia is a repair response of the body to damage. Repeated or persistent chronic liver parenchymal inflammation and necrosis caused by various etiologies can lead to continuous fibrous hyperplasia in the liver and form liv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/05A61P1/16A61P31/12
Inventor 黄兆胜
Owner 黄兆胜
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com