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Applications of ash tree flowers polysaccharide for preparing preventing and controlling fowl virosis medicament

A technology for avian viral diseases and Grifola frondosa polysaccharide, which is used in antiviral agents, pharmaceutical formulations, organic active ingredients, etc.

Inactive Publication Date: 2008-08-27
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the clinical research and product development of Grifola frondosa polysaccharides for anti-viral diseases of poultry

Method used

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  • Applications of ash tree flowers polysaccharide for preparing preventing and controlling fowl virosis medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Therapeutic Effect of Grifola frondosa Polysaccharide on Chicken Newcastle Disease

[0012] Treatment test in the artificial pathogenic virus model. 54 SPF chickens were artificially infected with Newcastle disease virus to cause Newcastle disease in the chicks. At the same time, they were randomly divided into 3 groups, 18 in each group. Group A is the "Grifola frondosa polysaccharide" treatment group, and the mass percentage content of Grifola frondosa polysaccharide is 30%; Group B is the treatment group of Astragalus polysaccharide, and the mass percentage content of Astragalus polysaccharide is 30%; Group C is the control group, Treatment with normal saline, 3 groups of chickens were infected with Newcastle disease virus at the same time, and each chicken was given nasal drops of 0.2ml of Newcastle disease virus strong poison. Once a day, the chickens in group B were injected with 0.5ml of stilbene polysaccharide, once a day, and the chickens in group C were inject...

Embodiment 2

[0018] Grifola frondosa polysaccharide inhibits chicken embryo pathogenicity caused by infectious bursal virus (IBDV)

[0019] 40 experimental chicken embryos were randomly divided into 4 groups: Group 1 was the no-drug group, which was used as a normal saline control group, Group 2 was the 1:2 Grifola frondosa polysaccharide group (polysaccharide content was 0.24 mg / ml), and Group 3 was the 1:2 group. 4 Grifola frondosa polysaccharide (polysaccharide content is 0.12mg / ml), 4 groups of Astragalus polysaccharide group (polysaccharide content is 0.24mg / ml). Dilute "Grifola frondosa polysaccharide" and Astragalus polysaccharide in 1:2 or 1:4 times respectively, and mix the different dilutions with equal volumes of spare virus liquid, and act at 37°C for 1 hour and pass through the allantoic cavity respectively. Inoculate 10 10-day-old SPF chicken embryos each, 0.2ml per embryo, and then continue to incubate the chicken embryos at 37.5°C, illuminate the eggs once every 12 hours, a...

Embodiment 3

[0026] Clinical treatment test Select typical chickens with infectious bronchitis, and divide 54 chickens into 3 groups randomly. Group A takes 5 mg of Grifola frondosa polysaccharide per bird; Group B takes 5 mg of Astragalus polysaccharide per bird. Group C received normal saline orally.

[0027] Experimental results

[0028] Table 3 "Grifola frondosa polysaccharide" treatment of chicken infectious bronchial disease test results

[0029] group

[0030] It can be seen from Table 3 that the effective rate of the "Grifola frondosa polysaccharide" test group was 83.3%, and that of the oral saline group was 22.2%. It can be seen that Grifola frondosa polysaccharide has a good therapeutic effect on chicken infectious bronchitis.

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Abstract

The invention discloses an application of Grifola frondosa polysaccharide when preparing the machine for preventing fowl virosis. The clinical study proves that the Grifola frondosa polysaccharide has good therapeutic efficacy to fowl virosis, more particularly gets rid of the clinical symptoms caused by virus infection, lowers the mortality of the disease fowls, and helps fowls with the disease to recover ingestion. Fowls with the disease can be fully recovered in 5 to 7 days, and the curative effect is remarkable.

Description

technical field [0001] The invention relates to the application of the frondosa frondosa polysaccharide, in particular to the application of the frondosa frondosa polysaccharide in the preparation of medicines for preventing and treating avian viral diseases. Background technique [0002] With the development of the society, the prosperity of the economy and the change of the concept of human health, the concept of returning to nature and the unity of man and nature has been more and more respected, "table safety" has received great attention, and people's requirements for food safety getting higher and higher. Among poultry diseases, virus infection causes the greatest loss to the poultry farming industry. Chicken infectious bursal disease, chicken Newcastle disease, and chicken infectious bronchitis are the three major diseases that endanger the poultry industry. In some areas where chickens are densely raised, they have replaced atypical Newcastle disease and ranked firs...

Claims

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Application Information

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IPC IPC(8): A61K36/06A61K31/715A61P31/12
Inventor 古长庆
Owner TIANJIN SHENGJI GRP CO LTD
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