Process for preparing corydalis saxicola bunting total alkali

A technology of Coptis chinensis and alkali precipitation, applied in the field of natural medicine, can solve the problems of increasing equipment cost and prolonging the production cycle, and achieve the effect of short production cycle

Active Publication Date: 2008-07-30
NANJING ZHONGSHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The improvement of the content is beneficial to the curative effect of the drug and the preparation of pharmaceutical preparations, but both ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take Litectinus chinensis medicinal material, soak it in 1% hydrochloric acid aqueous solution with 10 times the weight of the material for 8 hours, reflux extraction 3 times, add 10 times the amount of the above solvent for 1.5 hours each time, combine the extracts, filter, and add alkali to adjust the pH to 6-7, concentrate to a relative density of 1.2, add 1.0% hydrochloric acid aqueous solution to 8 times the weight of the medicinal material, reflux, extract twice, each time for 1.5h, filter, combine the acid and water, and use 30% sodium hydroxide Adjust the pH of the solution to 6-7, concentrate to a relative density of 1.06, refrigerate for 24 hours, centrifuge, add 1.0% hydrochloric acid solution equivalent to 8 times the weight of the precipitate to reflux each time, extract twice, each time for 1.5 hours, filter, Combine the acid and water, adjust the pH to 6-7 with 30% sodium hydroxide solution, concentrate to a relative density of 1.05, refrigerate for 24 hou...

Embodiment 2

[0020] Take Litectin chinensis medicinal material, soak it with 0.5% sulfuric acid aqueous solution equivalent to 10 times the weight of the medicinal material for 12 hours, then percolate with 40 times the amount of 1% hydrochloric acid aqueous solution at a flow rate of 5ml / min, add alkali to the percolation solution to adjust the pH to 6-7 , concentrated to a relative density of 1.12, added to an amount equivalent to 8 times the weight of the medicinal material, refluxed with an aqueous solution of sulfuric acid containing 0.5%, extracted twice, each time for 1 hour, filtered, combined with the acid and water, adjusted to pH 6-7 with sodium carbonate, concentrated When the relative density reaches 1.05, refrigerate for 24 hours, centrifuge, add 0.5% sulfuric acid solution equivalent to 8 times the weight of the precipitate to reflux each time, extract twice, 1.5 hours each time, filter, combine the acid and water, and use sodium carbonate solution Adjust the pH to 6-7, conce...

Embodiment 3

[0022] Take the Litectinus chinensis medicinal material, soak it in 2.0% acetic acid aqueous solution with 10 times the weight of the material for 2 to 12 hours, reflux extraction 3 times, add 10 times the amount of the above solvent each time for 1.5 hours each time, combine the extracts, filter, and add alkali Adjust the pH to 7-8, concentrate to a relative density of 1.15, add 2.0% acetic acid aqueous solution to 8 times the weight of the medicinal material, reflux, extract twice, each time for 1.5h, filter, combine the acid and water, adjust with sodium carbonate PH to 7-8, concentrate to relative density to 1.06, refrigerate for 24 hours, centrifuge, add 2.0% acetic acid solution equivalent to 8 times the weight of the precipitate to reflux each time, extract twice, each time for 1.5 hours, filter, acid water The solutions were combined, the pH was adjusted to 7-8 with sodium carbonate, concentrated to a relative density of 1.05, refrigerated for 24 hours, centrifuged, and...

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Abstract

The invention relates to the natural medicine field, in particular to a method for preparing total alkaloids of corydalis saxicola. Based on the total alkaloids crude extracts of corydalis saxicola and after repeated acid dissolving and alkali precipitating, the invention can make total alkaloids extracts of corydalis saxicola, the content of which is higher than 50 percent.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to a preparation method of total alkaloids of Litectinum chinensis. Background technique [0002] Yanhuanglian is a secret Chinese herbal medicine with special effects for treating hepatitis among the people in Guangxi. The original plant is Corydalis Saxicola Bunting. The clinically marketed dosage form is injection, which is recognized as a good medicine for liver treatment. The active ingredient of Yanhuanglian injection is total alkaloids of Yanhuanglian. It is mainly used clinically to treat acute jaundice hepatitis, chronic hepatitis B, moderate to severe hepatitis, especially icteric hepatitis. It removes viruses in liver cells, repairs liver damage cells, The effect of promoting cell regeneration and promoting bile excretion has been recognized clinically. [0003] The extraction method of total alkaloids of rhizome is generally extracted with acid water or ethanol, but th...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61P1/16A61P31/14A61P31/20A61K125/00
Inventor 成俊陆兔林黄芳毛春芹王巧晗郁红礼
Owner NANJING ZHONGSHAN PHARM CO LTD
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