Method for preparing amorphous biological activity superfine powder

A bioactive, ultra-fine powder technology, applied in the field of biomedical materials, can solve problems such as difficult preparation of nano-scale powders, and achieve the effects of convenient preparation, avoiding agglomeration, and high yield

Inactive Publication Date: 2008-07-09
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current problem is that it is difficult to prepare nano-scale powder due to t

Method used

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  • Method for preparing amorphous biological activity superfine powder

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Experimental program
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Effect test

Embodiment 1

[0020] To prepare amorphous bioactive ultrafine powder, follow the steps below:

[0021] (1) Ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate are added successively in the deionized aqueous solution containing the catalyst, and after fully stirring evenly, a transparent, uniform and stable sol is obtained, and the pH value of the solution is adjusted to 1 with hydrochloric acid; , the molar ratio of ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate is 60:4:36, and the molar ratio of deionized water to ethyl orthosilicate is 8:1;

[0022] (2) aging the sol obtained in step (1) statically at room temperature for 4 days to form a wet gel;

[0023] (3) placing the wet gel obtained in step (2) in a drying oven at 80°C for 2 days to obtain a dry gel;

[0024] (4) Place the xerogel obtained in step (3) in an electric furnace, and heat-treat at 600°C to obtain a granular sol-gel bioactive material;

[0025] (5) Mixing the granular sol...

Embodiment 2

[0028] To prepare amorphous bioactive ultrafine powder, follow the steps below:

[0029] (1) Ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate are added successively in the deionized aqueous solution containing catalyst, and after fully stirring evenly, a transparent, uniform and stable sol is obtained, and the pH value of the solution is adjusted to 3 with nitric acid; , the molar ratio of ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate is 80:4:16, and the molar ratio of deionized water to ethyl orthosilicate is 12:1;

[0030] (2) aging the sol obtained in step (1) statically at room temperature for 7 days to form a wet gel;

[0031] (3) placing the wet gel obtained in step (2) in a drying oven at 140° C. for 3 days to obtain a dry gel;

[0032] (4) placing the xerogel obtained in step (3) in an electric furnace, and heat-treating at 700°C to obtain granular sol-gel bioactive materials;

[0033] (5) The granular sol-gel bioa...

Embodiment 3

[0036] To prepare amorphous bioactive ultrafine powder, follow the steps below:

[0037] (1) Add ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate in sequence to the deionized aqueous solution containing the catalyst, stir well to obtain a transparent, uniform and stable sol, and adjust the pH of the solution to 2 with hydrofluoric acid ; Wherein, the mol ratio of ethyl orthosilicate, triethyl phosphate, and calcium nitrate tetrahydrate is 70:4:20, and the mol ratio of deionized water and ethyl orthosilicate is 10:1;

[0038] (2) aging the sol obtained in step (1) statically at room temperature for 6 days to form a wet gel;

[0039] (3) placing the wet gel obtained in step (2) in a drying oven at 100°C for 2.5 days to obtain a dry gel;

[0040] (4) placing the xerogel obtained in step (3) in an electric furnace, and subjecting it to heat treatment at 650° C. to obtain granular sol-gel bioactive materials;

[0041] (5) The granular sol-gel bioactive ma...

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Abstract

The invention discloses a process for preparing amorphous bioactive superfine powder, which comprises: sequentially adding ethyl orthosilicate, triethyl phosphate and calcium nitrate tetrahydrate in deionized water solution containing accelerating agent to obtain transparent homogeneous stable collosol and adjusting pH value; statically ageing the collosol for 4-7 days, then placing in a dry box at a temperature of 80-140DEG C for 2-3 days and further placing in a electric stove to obtain particulate sol-gel bioactive material via heat treatment of 600-700DEG C; mixing with grinding media and organic solvent to wet-grind for 5-12 hours, centrifugating, removing the organic solvent, further adding water, freezing and drying and directing sublimating the water after being frozen to obtain the amorphous bioactive superfine powder. The process of the invention is simple and practical and easy to control, and can realize mass production with the advantages of high production and uniform components, thereby effectively avoiding fine particles agglomerating.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a method for preparing amorphous bioactive ultrafine powder. Background technique [0002] Currently clinically used bioactive materials for bone defect repair (Na 2 O-CaO-SiO 2 -P 2 o 5 system) is obtained by high-temperature melting method, which requires high equipment requirements, harsh process conditions, and is difficult to control, and the product components are not easy to be uniform, and are easily polluted by trace elements in the crucible. Preparation of CaO-SiO by Sol-Gel Technology 2 -P 2 o 5 Systematic amorphous bioactive materials are a new technology, which can make the structure and composition of the prepared materials reach the uniformity at the molecular level. The bioactive material prepared by this method has a large specific surface area, and nano-scale micropores and aggregates are evenly distributed in the material structure. Studies have show...

Claims

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Application Information

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IPC IPC(8): C04B35/14C04B35/624A61L27/10A61L31/02
Inventor 陈晓峰郭常亮王迎军李玉莉赵娜如吴刚叶建东魏坤宁成云任力
Owner SOUTH CHINA UNIV OF TECH
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