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Fluid analysis device and method

An analysis device and analysis method technology, applied in chemical instruments and methods, fluid controllers, dissolution, etc., and can solve problems such as inability to provide versatility

Inactive Publication Date: 2008-07-02
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing devices do not offer this versatility

Method used

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  • Fluid analysis device and method
  • Fluid analysis device and method
  • Fluid analysis device and method

Examples

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Embodiment Construction

[0057] Figure 1 diagrammatically shows a device 1 according to the invention. Here, reference numeral 10 denotes a porous substrate having a first surface 12 and a second surface 14 . Reference numeral 16 denotes a first cavity and reference numeral 18 denotes a second cavity.

[0058] The pump is indicated with reference number 20 . The return channel 22 connects the first cavity 16 and the second cavity 18 via the first opening 32 and the second opening 30 and can be closed by the return channel valve 24 .

[0059] The sample fluid introduction device 26 can be closed via a sample valve 28 .

[0060]The pump 20 includes a pump cavity 40 and an equalization cavity 42 having a pump inlet 44 separated by a flexible membrane 46 .

[0061] Porous substrate 10 may be any suitable type of substrate known in the art. For example, non-woven fabrics, polished and etched hollow fiberglass or other material based substrates, electroformed substrates, etc. may be used. Preferably, t...

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Abstract

The present invention provides an analytical device (1) and method which are capable of repeatedly pumping a sample fluid (50) with one or more analytes through a substrate even when the wetted substrate has a relatively low bubble pressure (10), the substrate (10) has one or more attachment materials. Furthermore, the device (1) comprises a first cavity (16) and a second cavity (18), a return channel (22) provided with a valve (24) and a pump (20). The pump (20) can establish a pressure differential between the first cavity (16) and the second cavity (18) to pump the sample fluid (50) through the substrate (10), thereby allowing the analyte to adhere to the substrate superior. By opening the valve (24) and establishing an opposing pressure differential, the sample fluid (50) bypasses the substrate (10) through the return channel (22). After closing the valve, the device is ready for subsequent cycles, if required. The device and method can in principle analyze any volume of sample fluid and can use any type of substrate divided by bubble pressure, thus being more versatile and reliable.

Description

technical field [0001] The present invention relates generally to fluid handling, particularly in analytical devices or methods. Background technique [0002] Before describing the present invention in more detail, some background information that may assist in further understanding of the present invention is first provided. [0003] Analysis is usually performed in order to probe the quality and / or quantity of components of a (liquid) sample, in particular with regard to detecting the presence or amount of a particular DNA or RNA sequence or protein in the sample. Especially PCR, Polymerase Chain Reaction has greatly contributed to the development of all types of assays for detecting the presence of DNA, RNA sequences. Currently, DNA-containing samples can be collected from organisms to determine whether or how much a particular DNA sequence is present. Techniques can be used simultaneously to perform this multi-target sequence analysis, so-called multiplex detection of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01F13/00
CPCB01L3/5023B01L3/50857B01L2400/0475
Inventor J·F·莫勒纳尔A·W·D·M·范登·比加特
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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