Sesquiterpenoids, composition thereof, method for extracting the same from plants and application
A technology of sesquiterpenoids and compounds, applied in the field of medicinal chemistry, can solve the problems of narrow therapeutic range and high toxicity
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[0055] The preparation method of sesquiterpene compound of the present invention
[0056]As mentioned above, the compounds of the present invention are natural products. Natural products such as compounds of formula Ia, Ib or Ic can be extracted from plant extracts of the family Chrysanthaceae. The genus belonging to the Chloranthus family is selected from Sarcandra, Chloranthus or Hedyosmum. The species of the genus Chloranthus is preferably selected from the group consisting of C. angustifoliu, C. oldhami, C. spicatus, C. holostegius, C. anhuiensis, C. tianmushanensis, C. henryi, C. sessilifolius, C. fortunei, C. elatior, C. japonicas , C. serratus and C. multistachys. In a preferred embodiment, the Chloranthus species is Chloranthus spicatus. These natural products can be obtained from active site extracts. Using the method according to the invention an active fraction extract can be produced.
[0057] Therefore, the present invention provides a method for extracting s...
Embodiment 1
[0076] Total extracts of Chrysanthemum officinalis with antifungal activity
[0077] The dried whole plant of Chloranthus spicatus (10kg) was pulverized into powder, soaked and extracted with ethanol at room temperature for 3 times, each time for 3 days, filtered and evaporated to dryness of the ethanol solution to obtain the total ethanol extract (475g).
Embodiment 2
[0079] Extracts from active parts of Chrysanthaceae plants with antifungal activity
[0080] The total extract in Example 1 was dissolved in 20L distilled water to make a suspension, which was extracted with ethyl acetate and n-butanol successively to obtain 300g of ethyl acetate extract; 300g of ethyl acetate extract was subjected to silica gel column layer Analysis, gradient elution with petroleum ether-acetone by volume ratio 100:0, 20:1, 10:1, 5:1, 3:1 and 1:1, received a total of six fractions, each fraction received 1500ml; the organic solution of fractions eluted at a volume ratio of 5:1 was evaporated to dryness to obtain the active site extract (16.9g).
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